作为全氟辛基磺酸和羧酸（PFOS、PFOA）等受限制物质的替代品，新型全氟/多氟化合物（PFASs）的生产使用在快速增长，其在环境中污染水平出现上升的趋势。然而，关于这些新型PFASs在环境中迁移转化和归趋的研究才刚刚起步，无法支撑科学评估其生态环境风险的重大需求，亟需开展系统的研究工作。本项目拟以典型的新型全氟/多氟化合物为研究对象，结合野外调查和实验室微宇宙实验，通过生物暴露实验、离体培养实验、分子模拟实验等多种手段，系统研究新型PFASs化学结构和理化性质对其在水体多界面（水、固体颗粒物、气溶胶）间分配行为的影响机制；考察其在不同生物体中的积累动力学与过程，阐明其与不同性质的生物蛋白大分子、磷脂膜等结合对其积累和清除的构效关系，明确其生物积累机制；探索其在不同生物体中以及微生物作用下的转化过程和机制,为准确评价全氟替代物在环境中的生态风险以及为管理部门制定科学的管理规范提供理论依据。

As substitutes of perfluorooctane sulfonate (PFOS), perfluorooctane carboxylates (PFOA) and related substances, the production and usage of emerging per- and polyfluoroalkyl substances (PFASs) are increasing. Their global environmental concentrations display an increasing trend, and there is a potential that they are transformed to traditional PFOS, PFOA and other perfluorinated alkyl acids. However, there are great knowledge gaps on the environmental transport and fate of these emerging PFASs, it is urgent to conduct systematic researches. The target compounds in this project are typical emerging PFASs. The objectives are: 1) to investigate the their partitioning behaviors and the intrinsic mechanisms between the interfaces such as solid particle-water, water-aerosol, by integrating field study, lab-based batch studies and modern analytical techniques; 2) to investigate the bioaccumulation potentials and kinetics of there emerging PFASs in different bio-organisms by conducting field studies and lab-based microcosm studies; 3) The relationship between the chemical structures and chemicophysical properties and interaction affinities of the target compounds to the biological proteins and membrane lipids will be systematically investigated, which will shed light on the accumulation mechanisms of the target compounds; 4) to study the degradation of the target compounds in various tissues of the organisms using both in vivo and in vitro experiments. We try to delineate the transformation pathways and mechanisms, and illustrate the active sites where the transformation takes place; 5) to study the microorganism transformation potentials and pathways of the target compounds in soil, sediment and sludge. The research results of this project will lay theoretical basis for accurate risk assessment of the emerging PFASs and provide scientific evidences for their effective management in the environment.