Med23调控T淋巴细胞免疫稳态的机制

T淋巴细胞作为免疫系统的关键成员以及免疫应答的主要参与者，其自身免疫稳态的维持是机体免疫系统稳态维持的重要组成部分，对机体生理平衡具有重要的意义。T淋巴细胞免疫稳态的维持是一个多因子参与的复杂生理过程，但此过程中关键的转录调控仍然不清楚。作为转录中介体复合物尾部的一个重要组成亚基，Med23在转录组整体水平的调控起着不可或缺的作用。我们初步的研究结果表明，在T淋巴细胞中特异性敲除Med23后，小鼠外周T淋巴细胞亚群的比例及数量显著降低，而且T淋巴细胞的静息状态及功能发挥均遭到破坏。这表明Med23在免疫系统，尤其是T淋巴细胞免疫稳态的维持中发挥着重要的作用。接下来将系统分析Med23在T淋巴细胞免疫稳态维持中的功能，研究Med23调控T淋巴细胞免疫稳态维持的分子机制，揭示Med23及其介导的免疫稳态维持在自身免疫病和肿瘤免疫中的作用及调控机制，为相关疾病的治疗提供新的分子线索和诊疗思路。

T lymphocytes are pivotal components of the adaptive immune system and serve as the key regulator of immune response. The immune homeostasis of T lymphocytes, as a significant part of immune system homeostasis, plays an important role in maintaining the physiological checks and balances. Many studies have revealed that multiple genes and transcription factors are involve in the maintenance of the immune homeostasis of T lymphocytes, yet the regulation mechanisms are largely unknown. Med23, which is an important subunit of the mediator complex tail motif, participates in controlling the overall level of transcriptional regulation and the crosstalk between multiple signal pathways. In order to uncover the function of Med23 in immune system, we established T lymphocyte-specific Med23 knockout mice. Our results showed that the proportion and the cell number of peripheral T lymphocytes were significantly reduced in Med23 knockout mice compared to wild type mice, and the knockout mice showed obvious defection in the maintenance of T lymphocyte quiescence. These data indicate that Med23 plays an important role in immune system, especially in maintaining the immune homeostasis and normal function of T lymphocytes. In this project,we will further study the function and regulation mechansim of Med23 in maintaining the immune homeostasis of T lymphocytes, and explore the role of Med23 in the regulation of autoimmunity disease as well as T cell anti-tumor function.