银屑病是一种慢性炎症性免疫相关皮肤病，研究显示Th1/Th2、Th17/Treg细胞平衡扮演了重要角色。我院消银方治疗银屑病有良好疗效，治疗机制可能与改善Th1/Th2、Th17/Treg失衡有关。IL-6作为Th1型细胞因子在调节Th17细胞分化中具有关键作用，那么IL-6及相关IL-6/STAT3信号通路是否为Th1/Th2与Th17/Treg失衡的联系点呢？本研究以IL-6/STAT3信号通路为着眼点，以银屑病K5.STAT3C小鼠模型及其外周血T淋巴细胞为实验对象，检测通路相关基因(STAT3、CyclinD1、c-Myc、SCOS3)表达水平、STAT3基因转录功能、以及Th17细胞分化，构建靶基因表达质粒并转染淋巴细胞，明确消银方作用靶点。阐明消银方基于IL-6/STAT3信号通路对Th17/Treg的影响，为进一步研究银屑病发病机制和中药现代化治疗提供初步实验依据和理论基础。

Psoriasis is a kind of chronic inflammatory immune-related skin disease. Studies have shown that Th1/Th2 and Th17/Treg balance play an important role. Xiaoyin recipe of our hospital are effective to treat psoriasis. The treatment mechanism may be related to the improvement of Th1/Th2 and Th17/Treg imbalance. IL-6 as a Th1-type cytokines has a key role in the regulation of Th17 cell differentiation The study based on IL-6 and IL-6/STAT3 signaling pathways. In K5.STAT3C mouse model and peripheral blood T lymphocytes, we detect the expression level of pathway related genes (STAT3, CyclinD1, c-Myc, SCOS3) , Th17 cell differentiation, as well as STAT3 transcriptional functions. We build target gene expression plasmid and transfect lymphocytes to elucidate the clear target. After clarifing the effect of Xiaoyin recipe to Th17 / Treg based on IL-6/STAT3 signaling pathway, the study provide experimental evidence and theoretical basis for further studying the pathogenesis of psoriasis, the modernization of traditional Chinese medicine treatment.