远处转移是制约鼻咽癌疗效提高的关键因素。只有鉴定出与鼻咽癌转移相关的因素，系统阐明其作用和机制，才能指导临床甄选出高转移风险患者进行个体化治疗，从而达到提高疗效的目的。我们前期研究发现：①一组11个miRNA可准确地区分转移和非转移鼻咽癌，其中miR-34c-5p在转移鼻咽癌组织中表达明显降低；②miR-34c-5p可抑制鼻咽癌细胞的迁移和侵袭，生物信息学分析发现MET是其调控靶点。在此预实验基础上，我们提出假说：miR-34c-5p通过靶向MET基因抑制鼻咽癌细胞的侵袭和转移，可预测鼻咽癌患者发生远处转移的风险。本项目拟在此科学假说的基础上，首次揭示miR-34c-5p在鼻咽癌转移中的作用和机制，并明确其在鼻咽癌远处转移预测中的价值，通过本项目的实施，可为鼻咽癌治疗提供新的靶点，并指导临床甄选出高转移风险患者进行个体化治疗。

Distant metastasis is a key factor restricting to improve curative effect of nasopharyngeal carcinoma. Thus, there is a need to identify metastasis-related factors and clarify its function and mechanism, in order to guide clinical selection of high risk patients for individual therapy, so as to achieve the goal of improve curative effect. Our previous study found that: ① a set of 11 miRNAs could accurately distinguish patients with high metastasis potential from patients with low metastasis potential, among them miR-34c-5p was obviously decreased in patients with high metastasis potential. ② miR-34c-5p inhibits cell migration and invasion of nasopharyngeal carcinoma, and MET was predicted to be the target of miR-34c-5p. On the basis of the preliminary experiment, we put forward the hypothesis that miR-34c-5p inhibits cell migration, invasion and metastasis by targeting MET in patients with nasopharyngeal carcinoma. This project is proposed on the basis of the scientific hypothesis, which would first clarify the function and mechanism of miR-34c-5p in nasopharyngeal carcinoma, and evaluate its value in predicting distant metastasis. Through the implementation of this project, it can provide new targets for the treatment of nasopharyngeal carcinoma, and further guide clinical selection of high risk patients for individual treatment.