白血病干细胞（leukemia Stem Cells）被认为是白血病发生及复发的根源；研究证实：Wnt信号通路是在肿瘤干细胞自我更新功能中和与正常干细胞增殖及活化密切相关的一种信号通路,其信号通路中β-catenin核内水平增高是诱发肿瘤的关键环节。目前白血病的治疗仍以化疗和骨髓移植为主，治愈率尚不理想，从中药中开发针对抑制白血病干细胞增殖、诱导凋亡的特异性靶点的高效低毒的新药，已成为白血病治疗的研究热点和前沿。本课题组前期研究发现，从中药秦巴硒菇( Agaricus blazei Murrill-Qbsg)多糖中提取的酸性RNA蛋白复合物FA-2-b-β具有较强的抗肿瘤活性，能诱导白血病和胃癌细胞凋亡，且能协同端粒酶抑制剂叠氮胸苷（AZT）促使胃癌细胞凋亡，为进一步开发利用秦巴硒菇，本课题拟研究FA-2-b-β对白血病干细胞的影响。

Leukemia stem cells is considered to be the root cause of leukemia and relapse;Studies confirmed that Wnt signaling pathway are closely related to cancer stem cell self-renewal function and normal stem cell proliferation and activation. Increased β-catenin is the key to inducing tumor in this signaling pathway.Currently chemotherapy and bone marrow transplantation is still dominated in leukemia treatment, but the cure rate is not ideal.The efficiency and low toxicity new drugs which specifically target inhibition of leukemic stem cell proliferation and induce apoptosis developed from traditional Chinese medicine,have been become a hot research and the leading edge of leukemia treatment. Our prophase study found that FA-2-b-β is an acidic RNA-protein complex extracted from traditional Chinese medicine Agaricus blazei Murrill-Qbsg Polysaccharide. It has strong anti-tumor activity and inducing apoptosis in leukemia and synergistic function with telomerase inhibitors Azidothymidine(AZT) inducing stomach tumor cells apoptosis.For the further development of Agaricus blazei Murrill-Qbsg using, this study will research effect of FA-2-b-β on leukemia stem cells.