海马中BDNF与缺血性脑卒中运动功能恢复密切相关。BDNF功能的发挥需要它分泌释放，与受体TrkB结合使其磷酸化。CAPS1作为分泌激活蛋白，能够调控BDNF分泌，但CAPS1能否调控缺血性脑卒中运动功能恢复，目前未见报道。我们前期研究发现，缺血性脑卒中后海马内CAPS1及BDNF表达增加，且两者变化时间一致。有趣的是，在CAPS1增加的时间点，磷酸化TrkB升高，提示缺血性脑卒中后CAPS1可能调控BDNF分泌。由此，我们猜测海马中CAPS1可能通过影响BDNF分泌调控缺血性脑卒中运动功能恢复。本课题将在前期研究基础上继续探讨海马BDNF分泌对缺血性脑卒中运动功能恢复的影响；明确缺血性脑卒中后海马CAPS1的变化对BDNF分泌的调控作用及机制；以及CAPS1对缺血性脑卒中运动功能恢复的调控作用及其机制；为缺血性脑卒中的治疗提供新的干预靶点及理论基础。

The BDNF expression level in the hippocampus is closely related to motor recovery of ischemic stroke. The secretion of BDNF and its binding to TrkB receptor, lead to the dimerization and autophosphorylation of tyrosine residues and subsequent activation of downstream signaling molecules. As an activator protein for secretion, studies have shown that CAPS1 can regulate the secretion of BDNF. However, the role of CAPS1 on the motor recovery of ischemic stroke has not been reported. Our previous results showed that the expression of both CAPS1 and BDNF in hippocampus increased after ischemic stroke. In addition, the time curve of CAPS1 protein change is consistant with that of BDNF. Interestingly, the expression of phosphorylated TrkB elavated along with the CAPS1 increase, which indicate that CAPS1 may regulate BDNF secretion after ischemic stroke. Due to the important role of BDNF in motor function recovery of stroke, we speculate that CAPS1 is likely to participate in ischemic stroke motor recovery by regulating BDNF secretion. Based on the previous studies, we will study the effect of BDNF secretion on motor recovery in the hippocampus after ischemic stroke; the role of CAPS1 on regulating BDNF secretion in the hippocampus after ischemic stroke; the effect and mechanism of CAPS1 on motor recovery of ischemic stroke. This study will provide new intervention target and lay the theoretical foundation for the treatment of ischemic stroke in the future.