许多分子能在表面形成手性组装结构，这些分子可以是手性分子，前手性分子，甚至是非手性分子。非手性分子如何能形成表面手性结构，哪些非手性分子能形成表面手性结构，影响非手性分子形成表面手性结构的因素有哪些，是物理化学研究的基本科学问题。本项目拟以扫描隧道显微术为主要手段，结合其它方法及理论模拟，研究非手性分子形成表面手性结构的机理、转化及调控，主要内容包括：（1）非手性分子形成表面手性结构的分子机制,手性在表面的传递和转化；（2）非手性分子的结构与表面手性结构形成间的关系；（3）基底、溶剂、温度、电场等对非手性分子形成的表面手性结构的影响,各种弱相互作用在表面手性结构形成及转化中的作用；（4）利用非手性分子构筑特定整体手性的表面结构。该项目的实施将有助于对手性的起源这一基本科学问题的认识及对手性异相催化、手性分离与拆分等应用问题的理解，还可为手性纳米结构的设计构筑及其应用提供实验及理论基础。

Many molecules,includnig chiral molecules, pro-chiral moleucles, and even non-chiral molecules, can form chiral assembly on solid surfaces. How non-chiral molecules form surface chiral assembly? Which non-chiral molecules can form surface chiral assembly? Which factors will affect the chiral assembly of non-chiral molecules? These are the basic objects of physical chemistry study. By using scanning tunneling microscopy and theoretical simulations, this project plans to investigate the formation,transition and regulation of surface chiral assembly by non-chiral molecules. The main contents includ: (1) the molecular mechanism for the formation of chiral assembly by non-chiral molecules; (2) the relationship between the non-chiral molecular structures and the surface chiral assembly; (3) the effects of environment such as substrate, solvent, temperature, and electric field on the surface chiral assembly; (4) fabricate specific global chiral assemly by non-chiral. These investigations not only be helpful for the understanding of the origin of chirality in nature and the micromechanism of industrial applications of chirality such as enantio-selective heterogeneous catalysis, chiral separation and resolution, but also provides experimental and theoretical basis for the design and construction of chiral nanostructures.