基于离散选择实验的中国癌症人群QLU-C10D效用值积分体系构建与评估研究

癌症已位列我国疾病死因之首且发病率和死亡率仍呈上升趋势，相关医疗费用支出持续增长，癌症负担之重亟待破解。成本效用分析做为卫生技术评估领域最权威的经济学评价方法之一，已被决策者视为破解癌症负担的有效工具，而健康效用值的准确测量是实施成本效用分析的关键环节。本研究将对全球首个癌症特异性多属性效用量表QLU-C10D中文版进行评价。并基于随机效用理论，参照癌症多属性效用测量联盟（MAUCaC）制定的统一标化设计方案，利用离散选择实验法在线收集调查对象资料，通过计量经济学模型构建基于中国人群偏好的首个癌症特异性多属性效用量表效用值积分体系，并通过实证研究评估QLU-C10D效用值积分体系测量癌症患者健康效用值的适宜性。本研究能够开发出基于我国人群偏好的癌症患者健康效用值测量工具，可以有效降低卫生技术评估成本，为癌症诊治防护及相关政策制定提供循证依据；此外，还可以为相关研究提供方法学借鉴和参考。

Cancer ranks first in the cause of death in China, and the incidence and mortality are still on the rise. The medical expenses related cancer are still growing, and the burden of cancer needs to be solved. Cost utility analysis is one of the most standard methods of economic evaluation in the field of health technology assessment and is widely used in the field of cancer. Accurate measurement of utility values is a key part in CUA. This study will evaluate the first cancer-specific multi-attribute utility instrument (QLU-C10D Chinese version). Based on the theory of random utility, the standardization design developed by MAUCaC is used to collect the survey data online by discrete choice experiment, and the econometric model is used to construct China based on Chinese population preference. This study develops China's first cancer-specific multi-attribute utility value set based on the Chinese population preference through econometric model, and evaluates the suitability of QLU-C10D value set to measure the health utility value of cancer patients through empirical research. This study will develop a health utility instrument for cancer patients based on the preferences of the Chinese population, effectively reduce the cost of health technology assessment, and provide evidence for cancer diagnosis and treatment and related policy formulation; in addition, it can also provide reference of methods for related research.