性传播途径已成为我国艾滋病传播最主要方式。近年来，新型毒品在我国各地的迅速蔓延，新型毒品在艾滋病经性途径传播中的作用不可忽视。因此，本项目拟以上海市和浙江省台州市两地各280名新型毒品滥用人员组成研究队列，分别在加入队列时和加入队列后第12和24个月观察研究对象毒品使用、高危性行为、毒品使用网络、性网络和HIV、梅毒和HSV-2感染情况，结合流行病学、社会学和血清学研究达到以下研究目的：（1）掌握上海市和浙江省台州市新型毒品滥用人群中HIV、梅毒和HSV-2感染状态包括新发感染率及其影响因素；（2）确定高危性行为发生、高危性行为网络形成相关的毒品使用和毒品使用网络特征及因果关联；（3）掌握两地新型毒品滥用人群特别是其中HIV、梅毒和/或HSV-2感染者的性网络特征及动态变化。

Sexual transmission of HIV has become the primary mode of HIV infection in China. Recently, new-type drugs or club drugs have increased dramatically in China as well, the role of new-type drug abuse in increasing sexual transmission of HIV cannot be neglected. This study is designed to establish a cohort of 560 new-type drug users in Shanghai and Taizhou City of Zhejiang province. Blood sample will be taken to test for HIV,syphilis and herpes simplex virus 2 (HSV-2) and a structured questionnaire will be administered to collect information on socio-demographics, drug use, risky sexual behaviors, drug use networks and sexual networks at baseline,12 and 24 months follow ups. Using epidemiological, sociological and serological methods to achieve the following objectives: (1) to determine the prevalence and incidence of HIV,syphilis and HSV-2, and risk factors for infection among new-type drug users; (2) to examine the drug use and drug use network characteristics associated with HIV risky sexual behaviors and risky sexual networks; (3) to investigate the sexual network characteristics of new-type drug users particularly those infected with HIV, syphilis and/or HSV-2.