迄今为止，已发现了多种能够促进高等植物生长、提高抗病和耐逆的细菌、真菌类群，但具有丰富次级代谢产物的链霉菌对植物的促生抗病作用却少见系统的报道。前期研究发现奈良链霉菌JD211所产次级代谢产物环己酰亚胺类物质对植物病原真菌有较强的抑菌作用，链霉菌JD211对水稻有抗病促生效应，且改变了根际微生物群落结构。但该菌在土壤-植物体系中抗病促生的作用机理不清楚。本项目以链霉菌JD211为研究对象，分别从生理生化和分子生物学的角度，研究水稻与稻瘟病菌互作过程中链霉菌JD211对水稻防卫基因及相关蛋白调控作用的影响，在此基础上阐明链霉菌JD211对水稻的促生抗病机制，为明确拮抗菌的生态功能及其与植物互作的机理奠定理论基础。此项研究不仅对开发环保、安全的生防菌具有理论价值，而且可为农业可持续发展提供一条可行途径。

So far, a variety of bacterial and fungal taxa have been found, which can promote the growth of higher plants as well as improve their disease resistance and stress tolerance.However,the Streptomyces with rich secondary metabolites that could promote disease resistance ability of plants were rarely systematic reported. In the preliminary research, cycloheximide from Streptomyces naraensis JD211 could strongly inhibit the plant pathogenic fungi.Streptomyces JD211 has disease prevention and control, and growth promotion effects on rice, and changed the rhizosphere microbial community structure, but the mechanism of promoting disease resistance in the soil- plant system is unclear.In this project, Streptomyces JD211 was used as the research object.we have researched on Streptomyces JD211's defense role in regulating gene and related proteins of rice through the interaction process of rice and rice blast fungus from the perspective of physiological, biochemical and molecular biology,respectively.Thus, we can clearly define its ecological function of Streptomyces JD211 and its interaction mechanism with plants, which is very important significance in the mechanism of action about Streptomyces disease prevention and promotion. This project not only has a theoretical value of the development of environmental protection and safety production of anti-microbial agent, but also provides a feasible way for the sustainable development of agriculture.