骨科手术经常使用钛合金等金属植入物。当术后细菌感染不受抗生素控制时，病人需要进行伤口清创或手术移除植入物。因此，我们希望通过减少植入物表面的细菌黏附及细菌膜的形成，使植入物表面具抗菌功能，减低手术后细菌感染机会。纳米银具有良好的抗菌性，而HA则具有良好的骨诱导性。本项目拟研究在生物医用钛基合金表面进行激光合金化银-羟基磷灰石（Ag-HA）纳米复合材料，在钛合金表面形成稳定的纳米合金化涂层。一方面可抑制有害金属离子的析出，减少排异反应，同时探索表面合金化后的Ag-HA涂层的抗菌及生物相容性机制。本项目将研究激光合金化的纳米涂层与细菌之间的相互作用，并通过动植入试验,分析纳米涂层表面的抑制细菌膜生成效能及诱导新生骨组织形成情况，从而揭示激光合金化纳米Ag-HA涂层的抑菌机制及生物相容性机理.

Biomedical titanium alloys are widely used for orthopaedic applications, especially for the repair and reconstruction of bone tissues. However, the bad recognition of human body tissue and cell for these foreign implants, especially the rejection reaction between metal implants and surrounding tissues and the inflammation aroused from bacteria produced in this course usually induced the final failure of artificial bone implants.In this project we will combine the good antibacterial performance of nano siver particles with the great bone inductivity of HA to produce a stable Ag-HA nano coating on titanium alloys using laser alloying technique. Thus, on the one hand, it can restrain the leaching of harmful metal ions to reduce rejection reaction. On the other hand, we will explore the antibacterial mechanism of surface alloying nano Ag-HA coating as well as the biocompatibility mechanism of this coating. Ihe interactions between bacteria and nano Ag-HA coating will be investigated. Meanwhile, invivo tests will be carried out to explore the effects of nano Ag-HA coating on suppressing biofilm formation and inducing new bone tissue generation,thus reveal the antibacterial and biocompatible mechanism of this coating.