心力衰竭是至今未被攻克的心血管疾病。心衰时存在明显的能量代谢障碍，能量代谢障碍中的各环节已成为最新研究靶点。前期研究证实鹿红方能激活PI3K/Akt/eNOS通路、调节心肌线粒体功能干预能量代谢从而改善心衰。前期观察发现鹿红方能增加心衰患者血红蛋白（其生成受EPO调控）水平。近来研究发现，心肌缺氧时促红细胞生成素（EPO）分泌增多，与EPOR结合后激活PI3K使Akt磷酸化，增加线粒体合成。EPO来源和功能与中医藏象理论中肾精具有同一性，而基于“心肾相关”理论的鹿红方具有补肾益精活血功效。鉴于线粒体是重要的能量代谢细胞器，结合“能量代谢”这一目前研究心衰机制的热点，提出“鹿红方能显著改善心衰时能量代谢障碍，其机制可能是通过增加EPO、EPOR含量和表达，激活PI3K/Akt/eNOS通路调控线粒体合成”假说。拟从整体和细胞水平论证鹿红方对该途径的干预作用，为中医药防治心衰新靶点提供依据。

Heart failure is one of the most difficult cardiovascular disease to date.There are obvious energy metabolism disorders in heart failure,and the links in the energy metabolism disorder have become the latest research targets.Previous studies have confirmed that Luhong formula can improve heart failure by activating PI3K/Akt/eNOS pathway and regulating the function of myocardial mitochondria to intervent energy metabolism.Preliminary observation found that Luhong formula can increase hemoglobin(which is regulated by EPO) in patients with heart.failure.Recently,it has been found that when myocardium is during hypoxia,the secretion of erythropoietin(EPO) is increased.After the combination of EPO and EPOR,PI3K is activated and can make phosphorylation of Akt,and they can increase mitochondrial synthesis.The source and function of EPO is associated with kidney essence in Traditional Chinese Medicine theories.And Luhong formula which is based.on the “heart kidney correlation" theory can supplement the kidney,replenish essence and quicken the blood.Since mitochondria is important organelle for energy metabolism,and energy metabolism is the hot spot of current research on heart failure mechanism.The hypothesis is proposed that Luhong formula can significantly improve the energy metabolism disorder in heart failure.The mechanism may regulate.mitochondrial synthesis by increasing EPO、EPOR content and expression to activate PI3K/Akt/eNOS pathway.From the overall level and cell level to demonstrate the effect of Luhong formula interfereing with the pathway,and to provide basis of new target for prevention and treatment of heart failure by traditional Chinese medicine.