胃液隐血检测对胃癌、胃溃疡、食道癌等消化道疾病的筛查及诊断具有良好临床意义，但当前方法在便捷性、舒适性等方面仍存在诸多问题。基于前期智能胶囊的研究基础，本项目国际上首次提出了胃液隐血检测智能胶囊系统(Gastric Occult Blood Detecting Capsule,GOBDC)的研究，以实现无创、便捷、定位准确的胃隐血检测，前期研究结果得到了Medical Daily、Science Daily的评论，国际同行给与了关注及较高认可。本项目拟进一步推进该方向研究，深入研究微量隐血无创检测方法，研制胃液隐血检测芯片及智能胶囊系统，通过动物及志愿者实验进行方法验证。本项目融BioMEMS、芯片实验室、免疫检测等多学科知识与手段，可望取得原创性研究成果并发表较高水平论文，国际上取得领先地位。随着研究深入及技术突破，有望形成实用化的原创生物医学工程产品，具有重要研究意义和良好应用前景。

Gastric occult blood detection has a good clinical significance for screening and diagnosis of gastric cancer, gastric ulcers, esophageal cancer and other gastrointestinal diseases. But in current methods, there are still many problems in convenience, comfort, etc. Based on previous research of smart capsule, the project puts forward the Gastric Occult Blood Detecting Capsule (GOBDC) system for the first time in the world to realize gastric occult detecting with non-invasiveness, convenience and accurate position. Previous research was published and obtained comments form Medical Daily and Science Daily. International peer pay attention to the study and give a high recognition. The project intends to study non-invasive and efficient trace gastric occult blood testing methods further, develop gastric occult blood detecting chip and smart capsule system and verify it by animal and volunteer experiments. The project contains multi-disciplinary knowledge and means, such as BioMEMS, lab on a chip, immunoassays and so on. It is expected to get original research results, publish high level papers and achieve a leading position internationally. With the deepening of the research and technological breakthroughs, the project will form a practical original biomedical products and has important research significances and good prospects.