LCST可调节型温敏性高分子-仿生润滑性能的研究

发展无毒、生物相容性优异的温度响应型高分子功能表面在纳米科技和生物材料领域具有重要的意义。本课题将合成带有邻苯二酚功能基团的两嵌段P(MEO2MA-stat-OEGMA475)-b-PAEM/cat和三嵌段cat/PAEM-b-P(MEO2MA-stat-OEGMA475)-b-PAEM/cat聚合物。通过对高分子结构中MEO2MA和OEGMA475比例的设计使嵌段聚合物具有目标的LSCT (接近人体温度)，并以邻苯二酚作为吸附功能单元吸附高分子在SiO2表面，系统研究这些高分子在SiO2表面的吸附性能，获得高分子在表面吸附的基本参数和结构信息。进一步研究润滑性能与吸附层结构之间的对应关系。预期通过利用邻苯二酚与表面强的粘附作用力和PEGMA的强水合作用的特性获得具有优异润滑性能的功能表面，通过此研究阐明高分子分子结构、吸附层结构与润滑性能之间的结构与功能关系。

“Smart” polymers that respond to external environments, such as, temperature, pH, salinity, has been widely studied as a consequences of their applications in biomedical field. PEGMA based polymers show great biocompatible, thermo-responsive as well as tunable LCST, which are used as non-toxic alternatives to PNIPAM polymers for biomedical applications. In this present project, diblock copolymer, P(MEO2MA-stat-OEGMA475)-b-PAEM/cat, and triblock copolymer, cat/PAEM-b-P(MEO2MA-stat-OEGMA475)-b-PAEM/cat, will be synthesized by using ATRP. The LCST of the block polymers are designed to match aimed LCST (close to body temperature) by using proper ratio of MEO2MA and OEGMA475. Catechol groups in the polymers are used as anchor for adsorbing the polymers onto silica surface in aqueous solution, the structures of adsorbed polymer layers on silica surface will be investigated by QCM-D, XPS and AFM, the thermo-responsibility of the polymer layers will be studied as well. Moreover, The surface forces and friction forces between the polymer layers will be systematically investigated by AFM colloidal probe technique. Herein, we expect that the strong adhesive catechol and high hydrated PEGMA can achieve thermo-responsive polymer layers with excellent lubrication properties. It is believed that this project will provide a novel method for building non-toxic, thermo-responsive as well as excellent lubrication polymer layers on silica surface, providing promising tools in biomedical field.