基于卟啉限域贵金属单原子半导体MOFs的光电协同催化(杂)芳烃三氟甲基化反应研究

（杂）芳烃三氟甲基化合物凭借其独特的物理化学性质在农学、医学和材料科学等领域得到广泛研究和应用。针对（杂）芳烃三氟甲基化合物构筑策略中的基础技术难点和内在作用规律等关键问题，本项目拟制备并筛选结构稳定、性能优异的卟啉限域贵金属单原子半导体MOFs催化剂；通过调控MOFs组成结构、反应光源和偏压等，促进光生电子-空穴对分离，提升三氟甲基自由基的生成效率，从而提高（杂）芳烃三氟甲基化产物的产率和选择性，拓展（杂）芳烃底物的普适性并将其应用于目标药物分子的构筑。本项目通过构建半导体MOFs三电极光电协同催化（杂）芳烃三氟甲基化反应体系，揭示半导体MOFs光电协同催化高效实现（杂）芳烃三氟甲基化的作用机制和本质规律，发展稳定、绿色、高效的（杂）芳烃三氟甲基化新策略，实现半导体MOFs光电协同催化在有机合成化学方面的新应用，为多样化构筑（杂）芳烃三氟甲基化合物提供新思路和新方法。

(Hetero)aromatic trifluoromethyl compounds have been extensively studied and applied in agriculture, medicine and materials science due to their unique physical and chemical properties. To solve the key problems such as basic technical difficulties and internal function rules in the construction of (hetero)arene trifluoromethyl compounds, our project aims to prepare and screen stable and excellent semiconductor MOFs catalysts with noble-metal single-atom embedded in the center of porphyrin, promote the separation of photogenerated electron-hole pairs via adjusting MOFs composition, the light and bias voltage, enhance the productivity of trifluoromethyl radicals, improve the yield and selectivity of the (hetero)arene trifluoromethyl compounds, expand the scope of (hetero)aromatic substrates, and apply to the synthesis of target drug molecules. . Through the construction of a three-electrode photoelectric catalytic (hetero)aromatic trifluoromethylation reaction system, we also intend to explore the internal relationship and mechanism between reaction conditions and catalytic efficiency, develope a stable, green and efficient (hetero)aromatic trifluoromethylation reaction methodology, and achieve the application of semiconductor MOFs photoelectrocatalysis in organic synthesis chemistry, which could provide new ideas and new methods for the diversities in the construction of (hetero)aromatic trifluoromethyl compounds.