自组装胶体材料由于具有可调控的光学和结构特性而在生物分析和传感中发挥了巨大作用。本研究中，针对液体活检CTC相关研究过程中所面临的分离效率低与鉴定复杂等问题，我们提出利用微流控技术开发一种各项异性的、磁性胶体光子晶体微载体（“磁子”）进行生物分析。我们将以磁性内核-二氧化硅壳层的胶体颗粒作为结构单元，在微流控液滴模板中研究其限域组装过程；同时，我们将通过溶剂蒸发和磁场诱导，使液滴中的胶体颗粒在毛细力和磁场力共同作用下最终组装成紧密堆积的、各向异性棒状磁子。由于磁子具有有序排列的胶体晶体结构，其将被赋予结构色编码功能，此外，磁子还能够在磁场作用下发生定向迁移和转动，从而提升检测效率。基于此，我们将构建一种新型的多元液体活检技术，将所制备的磁子集成到优化的旋转磁场体系中，并应用于CTC等肿瘤标志物的高效捕获、分离及多元分析。

Self-assembled colloidal materials play an important role in bioanalysis and sensing because of their controllable optical and structural properties. Here, given the problem of low-efficiency separation and a lack of multiplexed assay in the detection of circulating tumor cells (CTCs) and other biomarkers in liquid biopsy, we propose to use microfluidic technology to develop a colloidal photonic crystal encoded, anisotropic magnetic microcarrier ("magneton"). The fabrication strategy involves the confined assembly of colloid particles in the microfluidic droplets template. The colloidal particles are generated with a magnetic core and a silica shell, which serve as the building block. Through solvent evaporation and magnetic field induction, the particles are finally assembled into a closely-packed, anisotropic rod-shaped magneton under the combined action of the capillary force and the magnetic force. The resultant magnetons possess an ordered colloidal crystal structure. It generates a distinct structure color that can be used as an optical coding element. In addition, the magnetons show magnetic responsive directional motion and rotation ability. Based on such magnetons, we will build a novel multiplexed liquid biopsy platform. By integrating the as-prepared magnetons into an optimized rotating magnetic field system, we would apply it to the efficient capture, separation and multiplex analysis of CTC and other tumor markers.