中药炮制与配伍是中医临床辩证用药的特色，但在配伍中探讨中药炮制机理的研究鲜有报道，导致临床组方中饮片炮制品的选择缺乏科学理论依据而只能依赖于临床医师的经验，制约了中药炮制和方剂学的发展。山茱萸与白芍配伍抗类风湿关节炎效应为临床所验证，课题组前期研究发现山茱萸和白芍酒炙后化学成分发生了显著改变，补益肝肾作用增强，并通过调节LGR4基因和蛋白表达发挥抗类风湿关节炎作用，但其酒炙配伍的增效机制尚未研究。故本项目以”山茱萸-白芍“药对为代表，采用“固有成分/代谢产物选择性捕捉-活性检识”模式，从体内外整体评价和分子生物水平入手，系统研究比较山茱萸和白芍酒炙及配伍前后化学成分、药效作用和体内动态过程的变化，阐明其酒炙增强抗类风湿关节炎作用的药效物质基础及LGR4靶向调控机制，揭示炮制配伍的科学内涵。本研究的开展将为酒炙山茱萸和白芍临床应用提供理论依据，同时为中药炮制配伍研究提供新思路。

Chines herbal medicine processing and compatibility are the characteristics of TCM clinic dialectical pharmacy, but the researches on discussing Chinese herbal medicine processing in compatibility are few, which result in that the selection of crude drug processed drugs in clinical composition is lacking scientific theory, but only depends on experience of clinicians, restricts the development of Chinese herbal medicine processing and science of prescription. Compatibility of Fructus corni and Paeoniae Radix Alba against rheumatoid arthritis effect is verified by clinic, in preliminary study, discover Fructus corni and Paeoniae Radix Alba occurs obvious changes after processing with wine,the function of nourishing liver and kidney reinforces, and give play to the function of anti-RA through regulating LGR4 gene and protein expression, but the synergia mechanism of frying wine’s compatibility has not researched, so this project takes Fructus corni and Paeoniae Radix Alba as representative, adopts the mode of “fixed composition/selective catch of etabolized product..active detection and recognition”, starts from witro and vivo comprehensive evaluation and molecular organism level,systematically analyzes and compares the change in chemical composition, pharmacodynamic action and internal dynamic process before and after processing with wine and compatibility of Fructus corni and Paeoniae Radix Alba, illustrates the pharmacodynamic material basis of wine enhancing the anti-RA effect and LGR4 target controlling mechanism, uncovers the scientific connotation of processing and compatibility. This research’s carrying out will provide theory evidence for clinical application of wining to Fructus corni and Paeoniae Radix Alba, and provide new thought for research on Chinese herbal medicine processing and compatibility.