多胺微环境对 DKK1功能及肝癌、乳腺癌转移性能的影响

阐明肿瘤微环境促进肿瘤转移的分子机制有助于新药研发以及肿瘤转移患者的治疗。我们研究发现DKK1高表达可促进肿瘤的侵袭与转移，而高多胺微环境可促进DKK1高表达。由于大部分肿瘤患者体内多胺含量异常升高，那么高多胺微环境如何调控DKK1进而促进肿瘤的转移是本申请课题研究的核心。应用体外细胞系、荷瘤动物、临床标本及原代培养等多种研究模型，从多胺微环境的角度出发，探讨肿瘤转移的分子机制，所得结果更接近临床实际，有助于深入了解肿瘤转移的机理和新药研发。

It could promote new drug research and therapies via elucidating the molecular mechanisms of tumor metastasis in microenvironment. Our recent results have shown that DKK1 overexpression could promote tumor cells invasion and metastasis. Furthermore, high polyamines microenvironment also up-regulates the DKK1 expression. The polyamines concentent of most cancer patients is often significant increase, so the important aim of this project is to elucidate the molecular mechanism that high polyamines microenvironment promotes DKK1 expression and tumor cells metastasis. These results from this proposal will help us understand the mechanism of tumor metastasis and promote new antitumor drug research via analysis of in vivo, in vitro and clinical specimen.