HHIP基因多态性与新疆维吾尔族、哈萨克族、蒙古族慢性阻塞性肺疾病易感性研究

刺猬相互作用蛋白质（HHIP）对于气道炎症发挥着重要作用。全基因组关联研究(GWAS)和综合基因组学方法显示HHIP多态性和非亚洲人群慢性阻塞性肺疾病(COPD)之间的关系。新疆维吾尔自治区是维吾尔族、哈萨克族、蒙古族等少数民族聚集区，COPD也是新疆常见的呼吸系统疾病。本课题拟采用病例对照方法对HHIP基因8个位点（rs1489758、rs1051730、rs8034191、rs2202507、rs1489759、rs10013495、rs13118928、rs1828591）多态性与新疆维吾尔族、哈萨克族、蒙古族COPD易感性关系进行研究，并观察HHIP基因8个位点多态性在新疆维吾尔族、哈萨克族、蒙古族人群分布特点，并观察HHIP基因8个位点多态性与COPD患者肺功能有无相关性，探讨各个基因位点的交互作用，进一步揭示HHIP基因多态性与不同民族COPD易感性的关系。

Hedgehog Interacting Protein (HHIP)plays an important role in airway inflammation .Genome-wide association studies (GWAS) and integrative genomics approaches have demonstrated the associations between HHIP polymorphisms and chronic obstructive pulmonary disease (COPD) and in non-Asian populations.This project will adopt a case-control study of HHIP gene of eight SNPs polymorphism and the Xinjiang Uygur, Kazak ,Mongolian people susceptibility to COPD relations, observation of HHIP gene of eight SNPs(rs1489758、rs1051730、rs8034191、rs2202507、rs1489759、rs10013495、rs13118928、rs1828591) polymorphism in the Xinjiang Uygur, Kazak ,Mongolian population distribution characteristics, observation of HHIP gene of eight SNPs polymorphism in the Xinjiang Uygur, Kazak ,Mongolian population distribution characteristics, and observation the correlation of HHIP gene of eight SNPs polymorphism and lung function of COPD patients，Discuss eight locus interaction of COPD. Further reveal the HHIP gene polymorphism with different ethnic susceptibility to COPD in the relationship, to elucidate the causes of COPD, of great significance.