动脉瘤、血管畸形、颈内动脉剥脱等手术中动脉的临时阻断经常导致动脉供血区域的缺血梗死。体感诱发电位（SEP）、脑电图（EEG）可通过脑电活动实时反映临时阻断过程中大脑的血流灌注状态，被广泛应用于临时阻断的监测中。但是临床研究发现SEP、EEG的报警标准有时不能准确的反映患者的预后，且目前主要通过脑血流量的改变来研究其变化时的机制，缺乏进一步分析此时相应功能皮层的神经活动。在前期实验中，我们利用光学成像技术（OIS）顺利的在大鼠脑损伤皮层上采集到缺血半暗带、脑梗死区域的光学信号。本研究中我们在国内外首次采用OIS定量研究大鼠局部脑缺血再灌过程中SEP、 EEG的变化与缺血半暗带、梗死中心、功能皮层神经活动之间的关系，建立SEP、EEG-OIS缺血半暗带、梗死中心区-术后神经功能之间的耦合关系。本课题将从新的角度阐明SEP、EEG的机制，为SEP、EEG在临时阻断技术中的使用提供更准确的理论依据

Temporary occlusion in the aneurysm, vascular malfomation,carotid artery exfoliative surgeries often lead to the ischemia.Introperative neurophysiological monitoring such as somatosensory evoked potentials(SEP), electroencephalogram(EEG) are used widely in these surgeries to prevent the ischemia, since they are able to reflect the cerebral blood fusion during the temporary occlusion in time. However, recent clinical studies found that the SEP,EEG can't predict the prognosis of patients exactly.Further, the mechanism of the SEP,EEG which explained by the changes of cerebral blood fusion is not clear, because we do not know the neuron's activities during this procedures. In our pre-studies, we recorded the optical imaging of intrinsic signals(OIS) of the penumbra and ischemia in the injury cortex of SD-rats succussfully. In this study, we intend to study the correlation between the SEP,EEG and ischemia, penumbra and the activity of the neurons in the local ischemia-reperfusion cortex quantitatively by OIS , and establish the couple relationship between the SEP,EEG-penumbra, ischemia-prognosis. This study will elaborate the mechanism of the SEP, EEG from a new perspective, and provide better application of the temporary occlusion.