系统性硬皮病（SSc）是一种以局限性或弥漫性皮肤及内脏器官纤维化、硬化为特征的结缔组织病。由于SSc患者病程长、病情相对较重、治疗困难，目前尚缺乏理想的治疗药物。Morphogen通路是一个进化上高度保守的信号通路，包括Wnt、Notch和hedgehog信号通路，在纤维化疾病中扮演了重要角色。刺山柑总生物碱是本课题组从新疆优势特色资源刺山柑中提取的一类天然生物碱类成分，对SSc模型小鼠及硬皮病患者均有良好治疗作用，其抗纤维化作用可能与Morphogen通路相关。本课题将基于Morphogen通路研究刺山柑总生物碱抗SSc组织纤维化的作用机制，为维吾尔药刺山柑治疗SSc创新药的研究提供理论指导，也为发掘利用这一传统的维吾尔道地药材奠定基础。

Systemic sclerosis (SSc) is regarded as a prototypical fibrotic disorder that affects the skin and many internal organ systems, including the lungs, the heart, and the gastrointestinal tract. Despite the high disease burden of SSc, potent anti-fibrotic therapy is not yet available in clinical routine. The morphogen pathways are a small set of evolutionarily conserved signaling pathways, including Wnt, Notch, and hedgehog. Growing evidence indicates that enhanced activation of Wnt, Notch, or hedgehog signaling is a driving force in a variety of fibrotic diseases. Total alkaloids of capparis spinosa is a kind of natural alkaloids from xinjiang characteristic advantage resources capparis spinosa with a potential protective effect against skin sclerosis in murine models and patients of SSc and its mechanism against SSc may be related to morphogen pathways according to our before research. Based on preliminary findings and the mechanisms of total alkaloids of capparis spinosa against SSc based on morphogen pathways will be investigated in this study. It will be established a theoretical basis for researching new drug from total alkaloids of capparis spinosa against SSc. This research will lay a certain foundation for drug discovery research on active ingredients from xinjiang property plant medicine.