祖国医学认为"痰毒互结"是AS重要病因病机，与炎症及氧化应激密切关系。CD40/CD40L信号通路在内皮损伤和AS发生中发挥重要的作用。虎杖中重要活性组分- - -白藜芦醇,具有抗炎、抗氧化应激和抑制细胞凋亡作用。我们前期研究发现，白藜芦醇可抑制sCD40L诱导的内皮细胞CD40表达和炎症因子产生，缩小了兔动脉粥样斑块，但具体机制未明了。白藜芦醇是SIRT1重要激活剂，推测白藜芦醇可能激活SIRT1及下游信号通路与CD40/CD40L信号通路产生对话，从而产生抗炎效应。本课题首先在体外实验中，观察白藜芦醇对人脐静脉内皮细胞CD40/CD40L及炎症介质、氧化应激及凋亡的影响；然后在CD40基因敲除小鼠和转染表达CD40载体前后，观察白藜芦醇干预对上述指标和动脉粥样斑块的影响，旨在探讨白藜芦醇新的抗炎症机制，为走向临床应用提供科学依据。

Atherosclerosis (AS) is belong to the phlegm and toxin syndrome in Traditional Chinese Medicine，which is close related with inflammation and oxidative stress. New data showed that immuno-inflammatory response mediated by CD40/CD40L signalling pathway is an importance pathological process of endothelial damage and AS. Resveratrol, as an important activators of SIRT1, can inhibit oxidative stress, inflammation and apoptosis. Our preliminary experiments showed Resveratrol significantly inhibited the expression of CD40 receptor of endothelial cells and inflammatory cytokines induced by CD40L in vitro, and reduced the area of AS plaque in AS. Based on these, we proposed that Resveratrol may play a role by activating SIRT1 to inhibit CD40/CD40L signalling pathway by inhibiting expression of CD40 receptor and other inflammatory mediators, reactive oxygen species and apoptosis in vitro and in vivo by CD40 gene knockout mice. We intend to investigate the effect of Resveratrol on resisting AS and explore its anti-inflammatory pharmacological mechanisms for its clinical application.