羟基磷灰石（HA）生物活性好、抗压强度高，聚乳酸（PLA）具有良好的生物相容性和降解性，而磁性材料能够刺激成骨细胞增殖分化，加速骨缺损的愈合，将三者复合既可解决人工骨的力学和生物学问题，又可诱导和刺激新骨形成。.本申请拟以纳米HA和PLA粉末为原料、以磁性四氧化三铁纳米颗粒为磁源、以选择性激光烧结为工艺，制备磁性纳米复合人工骨。研究制备过程中人工骨支架的组成与结构、颗粒的分散与团聚、晶粒的大小与结晶度等的演变规律，查明组分配比、制备工艺对力学性能和生物学性能的影响；重点研究四氧化三铁的磁学性能如磁导率、磁矩和外加磁场的强度大小、作用时间对细胞增殖、细胞活力及细胞形貌的作用机制，以及对矿化沉积和成骨能力的影响规律；通过查明磁性、降解速率、微观结构等与工艺参数的映射规律，建立多参数优化匹配的工艺模型；为发展具有我国自主知识产权的高性能磁性纳米复合人工骨制造技术与装备提供理论基础。

Hydroxyapatite (HA) possesses excellent bioactivity and good compressive strength. Poly (lactic acid) (PLA) has favorable biocompatibility and biodegradability, while magnetic materials can stimulate osteoblast proliferation and differentiation and promote the healing of bone defects. Therefore, the combination of these three materials can not only solve the mechanical and biological issues of artificial bone, but also induce and stimulate the formation of new bone..In this project, magnetic nanocomposite artificial bone will be fabricated with nano-HA and PLA powders as raw materials, magnetic ferroferric oxide (Fe3O4) nanoparticles as magnetic source and selective laser sintering as processing technique. The evolution rules of the composition and structure of artificial bone scaffolds, the dispersion and agglomeration of particles, as well as the size and crystallinity of grains during the preparation process will be studied. The effects of component ratio and preparation process on the mechanical and biological properties will be investigated. Emphases will be put on the mechanisms of the magnetic properties of Fe3O4 including magnetic permeability and magnetic moment, and the intensity and action time of external magnetic field on cell proliferation, viability and morphology, as well as the influence rules on mineralization and osteogenetic capability. Moreover, an optimized and matched multi-parameter process model will be established by identifying the mapping rules between the magnetic, degradation rate, microstructure, etc. and process parameters. These studies will provide the theoretical basis for the developments of manufacturing technology and equipment for high performance magnetic nanocomposite artificial bone with our own independent intellectual property.