子宫内膜异位症（内异症）是一种妇科常见病及难治病，其发病机制一直是妇科基础与临床研究的重点和热点。lncRNA作为非编码RNA中的新星，在多种疾病过程中起到关键作用。本项研究是在前期已经进行的对CREB1及wild-type BRAF在子宫内膜异位症中的作用及功能鉴定研究的基础上，首次应用生物化学、免疫学及分子生物学等方法对lncRNA-SNHG1进行功能鉴定，进一步研究lncRNA-SNHG1通过靶向调控CREB1基因参与wild-type BRAF/ERK信号通路影响内异症的发生和发展。首次阐明lncRNA-SNHG1在内异症中的分子作用机制，为寻找子宫内膜异位症源头分子机制及治疗靶点提供理论依据。

Endometriosis(EMs) is one of the most commonly benign gynecological disorders. The pathogenesis of EMs is the focal point and the hot spot of the clinical and scientific studies in gynecology.As a new star in non coded RNA, lncRNA plays a key role in a variety of diseases. In our previous study, we found overexpression of CREB1 and wild-type BRAF expression were significantly correlated with development of EMs.Our present study plans to first investigate the role and molecular mechanism of lncRNA-SNHG1 in pathogenesis of EMs with the method of biochemistry, immunology and molecular biology.And then investigate that lncRNA-SNHG1 regulate of biological behaviours of endometrial cells through wild-type BRAF/ERK signal pathway by transcriptional regulation of CREB1. We may finally demonstrate that lncRNA-SNHG1 plays a primal role on development of endometriosis, and explore the origin of pathogenesis of EMs, which provides a theoretical basis for finding the molecular mechanism of the source and the target of treatment of endometriosis .