HIV/AIDS 患者HAART治疗后免疫功能不全以及能量代谢障碍等毒副作用，成为现今国际主流医学防治艾滋病的瓶颈和难点之一。同时在HIV/AIDS患者免疫重建领域，如何正确评价中医药的临床疗效，诠释中医药治疗HIV/AIDS擅长领域的科学机制，已成为中医药能否融入国际艾滋病防治主流医学的关键问题所在。 . 本研究为延续性研究，依据项目团队前期研究证实益气健脾方药（艾宁颗粒加减）能够明显改善患者脾气虚损如乏力，腹泻等一系列症状，同时立足于已完成的国家自然基金青年项目研究结果，脾气虚损HIV/AIDS患者淋巴细胞能量代谢衰减以及黏膜免疫细胞过度激活的机制，试图从T淋巴细胞能量代谢及其黏膜免疫激活角度入手，揭示益气健脾方药对脾气虚损HIV/AIDS患者免疫系统功能在“扶正补虚和祛邪”两个方面的双向调节影响，为中医药辨证论治HIV/AIDS患者提供免疫学理论支持和更加理想的临床评价指标。

During the immune reconstitution of HIV/AIDS treated by HAART , the insufficiency of immune function and side effects of energy metabolism disorder, have become one of the bottlenecks which hindered the HIV/AIDS therapy in international mainstream medicine. Meanwhile, the correct evaluation on the clinical effect of traditional Chinese medicine (TCM) and the interpretation on the scientific mechanism of treatment of HIV/AIDS by TCM, which is the key problem about traditional Chinese medicine (TCM) integrated into international mainstream medicine of HIV/AIDS therapy . This research is continued research, given the preliminary results that Qi-boosting Spleen-fortifying prescripition (Aining granule ) had significant effects on the symptoms of spleen-Qi deficiency, such as fatigue, diarrhea, and based on the research results of the National Natural Science youth Fund that the decreased energy metabolism function of immune cells reduced and mucosal immune activated, we try to reveal the bidirectional regulation mechanism of the immune function in HIV/AIDS patients of spleen-Qi deficiency affected by Qi-boosting Spleen-fortifying prescripition on the strengthening the body resistance and eliminating evil , which provide the immunological support and more ideal clinical evaluation indexes for TCM treatment of HIV/AIDS based on syndrome differentiation.