花粉变应原引起的变应性鼻炎的患病率在逐年增长，而且城市增长率显著高于农村。城市的空气污染被认为是引起变应性鼻炎患病率增长的主要原因，污染物中易被吸入呼吸道的主要成分是汽车尾气颗粒物（DEPs）。本课题将以蒿属花粉颗粒及花粉过敏患者鼻粘膜上皮和肥大细胞为对象，通过不同浓度的DEPs刺激，验证DEPs对蒿属植物花粉的变应原性的影响以及对鼻腔粘膜上皮细胞和肥大细胞功能的影响。为了进一步给花粉症患者的个人防御提供有效的帮助，我们拟通过对花粉浓度、DEPs浓度和花粉症患者发病时间的相关性分析，尝试建立AR发病趋势的预报方程，以期为花粉症患者提供较好的个人防护指导。

The prevalence of pollinosis is increasing year by year, and the growth rate in urban significantly higher than rural. The city's air pollution is considered to be the main reasons for the growth rates. In particular, the main components which easy be absorbed into respiratory tract is diesel exhaust particles (DEPs). This topic focus on pollen grain and nasal mucosal epithelium and mast cells, discus the effect of DEPs to pollen allergenicity as well as to the nasal mucosa epithelial cells and mast cell functioning. Furthermore, to hay fever patients personal defense provide effective help, through analysis the correlation of pollen concentration, DEPs concentration and pollinosis onset time, we try to establish the prediction equation allergic rhinitis onset trend, to provide a personal protective guidance for pollinsis patients.