G2A是应激诱导的G蛋白偶联受体。近期研究发现G2A高表达于动脉粥样硬化（Atherosclerosis，AS）斑块内的巨噬细胞表面，但G2A对巨噬细胞的作用，既有促AS功能，也有抑AS功能。我们假设在AS的不同发展阶段，G2A所介导的巨噬细胞的作用可能不同。本项目以G2A对巨噬细胞的作用为切入点，以LDLR-/-小鼠为研究基础，运用MR管壁微观成像和巨噬细胞靶向技术动态监测和研究：AS演进过程中，G2A对巨噬细胞数量、表型变化的作用，进而建立可靠评估G2A作用的MR微观靶向技术及解析方法。本研究将较全面直观地揭示G2A在AS发展不同阶段对巨噬细胞的不同作用，从而为AS不同发展阶段的干预提供新思路。

G2A is a stress-induced G protein-coupled receptor. Recent studies have found that G2A is highly expressed on the surface of macrophages in atherosclerotic plaques. However, the effect of G2A on macrophages has the function of pro-atherosclerosis and anti-atherosclerosis. We infer that the role of G2A-mediated macrophages may be different during different stages of atherosclerosis. In this study, we aimed to investigate the effect of G2A on macrophages. Based on the LDLR-/- mice, microstructure MR imaging and targeting of a specific macrophage subpopulation were used to dynamically monitor and study the effects of G2A on macrophage apoptosis, phenotypic changes within carotid atherosclerotic lesions. based which an accurate and reliable MR protocol and data analysis method will be further built for the assessment the role of G2A in AS. So this study will reveal the different effects of G2A on macrophages during the development of AS in a comprehensive and direct way, providing new ideas for the treatment of different stages of AS.