基于新型磁靶向纳米材料高通量前处理技术的难测极性PPCPs多组分痕量分析研究

PPCPs作为集环境污染与食品安全问题于一身的新型污染物，其高通量多组分精准检测分析至关重要。然而，部分 PPCPs 极性强、极易溶于水，在样品前处理上仍十分困难，尚未找到解决此类难测物质较好的分析方法，且多类型PPCPs无法共同检测也已成为国际上待解决的关键问题。最近兴起的新型磁性材料前处理技术有望解决强极性PPCPs难检测分析的难题。本项目将主要针对PPCPs中的强极性物质，基于链接化学策略，靶向制备在水及有机介质中对极性PPCPs具有高选择性、快吸附的磁性离子交换材料；将其应用于环境和食品中极性PPCPs的综合样品前处理分析，发挥其简捷、价廉、基质干扰低、一步式高通量精准检测等特点，结合色谱分离新技术，建立极性PPCPs多组分检测技术平台。本研究将为环境和食品污染物前处理分析提供新思路和新方法，也为我国开展PPCPs环境污染和膳食暴露评估提供技术基础支持，具有重要的理论和现实意义。

As a new type of pollutants in environmental pollution and food safety issues, it is especially important for PPCPs to establish a high throughput and multi-component accurate analytical technique. However, some PPCPs are still very difficult to be extracted and analyzed in the complex environmental and food samples due to the characteristics of strong polarity and easily soluble in water, such as aminoglycoside and inorganic ions. For the strong polar PPCPs, the world, including the EU remain unavailable better analytical method. In addition, the multi-type PPCPs analysis has also become a key problem to be solved in the world. Recently, the developed magnetic materials are expected to solve the problem of detecting and analyzing the strong polar PPCPs. In this project, we tend to prepare the functional magnetic ion exchange materials based on the click chemistry strategy with the merits of high selectivity, fast adsorption rate for the polar PPCPs in aqueous and organic media. Then, this magnetic materials can be used as the adsorbent in sample pretreatment analysis of polar PPCPs. Ultimately, the rapid, inexpensive, low matrix effect and accurate detection methods are established for the determination of multi-type PPCPs coupled with the chromatographic separation technique. This study will provide new ideas and methods for sample preparation in environment and food security analysis, and also offer the technical basis for the environmental pollution and dietary exposure assessment of PPCPs in China, which has important theoretical and practical significance.