飞蝗长时程飞行过程中肌肉糖脂代谢转换的神经分子调控机制

长距离飞行是昆虫提高环境适应性的优化策略。飞行肌中糖脂代谢的能量转换是实现长距离飞行的重要生理基础。已有研究表明神经肽在飞行相关的能量代谢调控中发挥关键作用，但其如何调节飞行肌的能量转换尚不明确。基于前期的工作基础，我们拟以重大迁飞性农业害虫飞蝗为研究模型，围绕飞行过程中飞行肌的糖脂代谢动态变化及转换机制开展研究。拟采用“多组学”研究思路，结合多肽组、代谢组、转录组及基因操作等分子生物学技术，解析以下三个问题：①飞蝗飞行过程中糖脂代谢发生了怎样的动态变化？②哪些神经肽参与调控飞行肌糖脂代谢的转换？③飞行肌代谢转换调控的神经分子机制如何？本项目的开展不仅可以为蝗灾的绿色防控提供新思路，还将为理解对动物生存适应性机理提供重要参考。

Long-term flight is an optimal strategy for enhanced environmental adaption in insects. The carbohydrate-lipid metabolism transition is important physiological basis for long-term flight. Previous studies have revealed that neuropeptides play key roles in the regulation of flight-related energy metabolism. However, the mechanisms underlying energy transition in flight muscles remain unclear. In this project, we intend to analyze the dynamic changes of glycolipid metabolism and uncover the regulatory mechanisms underlying energy transition during flight, using the agricultural pest Locusta migratoria as a study model. We will employ “multi-omics” methods, including peptidome, metabolome, and transcriptome, combined with gene manipulation techniques, to analyze: ① How does glycolipid metabolism dynamically change in flight muscles during long-term flight? ② Which neuropeptides participate in the regulation of energy transition in flight muscles? ③ What are the detailed neural molecular mechanisms underlying energy transition in flight muscles? This project will not only provide new approach for the green prevention and control of locust outbreaks, but also provide insights for understanding the environmental adaption in animals.