高剪切湿法造粒中颗粒湿度测量及颗粒生长机理研究

高剪切湿法造粒是医药、能源等领域广泛应用的重要工艺，其颗粒湿度的在线监测是提高过程效率、成品质量和保证系统稳定运行的关键。但由于颗粒湿度在时间和空间上均呈现较大不均匀性，且水分所占量小，因此其在线监测是该工艺尚未解决的难点。传统的湿度测量手段无法实现非接触、非侵入实时在线监测，且无法获取参数的分布特征。针对此，本项目提出采用电容层析成像技术测量颗粒湿度并对颗粒的生长机理进行研究。首先，通过成像算法，重建颗粒介电常数的高质量图像。其次，结合电容值、电容敏感特性和相关模型进行数据融合分析，实现颗粒湿度和浓度的定量测量。然后，在理论分析和实验研究的基础上，构建粘性剪切力模型。最后，将构建的模型嵌入LIGGGHTS-PBM耦合模型，模拟颗粒运动特性和生长破碎过程，融合实验测量，验证模型的可行性并加以修正，揭示颗粒的生长机理。拟开展的理论和实验研究为推动造粒技术的更新和发展提供坚实的基础。

High shear wet granulation is an important technology which is widely used in pharmaceutical, energy and other industries. The process efficiency, end-point product quality and system’s operation stability strongly depend on the on-line measurement of particle moisture in the process. However, due to the non-uniform distribution of particle moisture in time and space, and the small quantity, its online monitoring is the difficulty which needs to be solved urgently. The traditional moisture measurement methods cannot achieve non-intrusive or non-invasive, real-time online monitoring, and cannot obtain its distribution characteristics. This project is proposed to measure the particle moisture by electrical capacitance tomography (ECT) and to study the particle growth mechanism. Firstly, imaging algorithm is used to reconstruct the high quality image for permittivity distribution. Secondly, the capacitance measurement, sensitivity characteristics and analysis models are combined to process the data and realize the quantitative measurement of particle moisture and concentration. Then, theoretical analysis and experimental measurements are performed to build the viscous shear force model. Finally, the viscous shear force model is embedded into the LIGGGHTS-PBM coupled model to simulate the particle movement characteristics and growth, breakage, the experimental results is fused to verify the force model’s feasibility and modify it, which can reveal the particles’ growth mechanism. The proposed theoretical and experimental research provide a solid foundation for promoting the optimization and development of granulation technology.