合并有糖尿病的冠心病患者冠脉表现为斑块弥漫、病变更长、斑块更不稳定，无论采用何种血运重建方式患者预后均较差。申请者已有结果显示HMGB-1参与糖尿病及其并发症的发生发展，但它在糖尿病促动脉粥样硬化中的作用仍不清楚。因此我们通过构建糖尿病动脉粥样硬化模型来观察HMGB-1对动脉斑块形态特征的影响，而体外实验则利用RNA干扰、免疫荧光等手段阐明HMGB-1介导的信号通路在泡沫细胞形成、炎症放大、细胞钙化中的作用。该研究将为糖尿病并发动脉粥样硬化提供理论依据及诊疗靶点。

Coronary artery disease in patients with diabetes exhibite diffuse atherosclerosis, longer lesions and vulnerable plaques, consequently, they have worse clinic outcomes after revascularization regardless of the modality. We have reported the contribution of HMGB-1 to diabetes and its complications, however, there is a paucity of data about the role of HMGB-1 on atherosclerosis with diabetes. Thus, diabetic atherosclerosis mice were established to explore the impact of HMGB-1 in plaque characteristics. Furthermore, RNA interference, immunofluorescence and other methods were performed to reveal the role of HMGB-1-mediated signaling in foam cell formation, inflammation and calcification. The present study will provide theoretic bases and therapeutic target for diabetic atherosclerosis.