内质网蛋白Ei24调控胰腺癌细胞迁移、侵袭的分子机制研究

批准号:
31970704
项目类别:
面上项目
资助金额:
50.0 万元
负责人:
袁琳
依托单位:
学科分类:
细胞极性与细胞运动
结题年份:
2023
批准年份:
2019
项目状态:
已结题
项目参与者:
袁琳
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中文摘要
胰腺癌是近年来发病率持续增加的一类恶性程度极高的消化系统肿瘤,由于其极具侵袭性、扩展迅速,胰腺癌患者平均五年内生存率极低,成为预后最差的实体恶性肿瘤。侵袭和转移能力是癌细胞区别于正常细胞的最基本特征,如何抑制胰腺癌细胞脱离原发肿瘤病灶、发生迁移和侵袭是国内外研究人员亟待解决的重要问题之一。针对这一问题,本项目拟从最有希望作为药物靶点应用于临床治疗的靶基因Ei24为切入点,详细阐明其在胰腺癌中低表达的原因,及其调控胰腺癌细胞迁移和侵袭的分子机制。本项目将为研发靶向药物、推动胰腺癌的治疗和预后提供理论基础和实施方向。
英文摘要
Pancreatic adenocarcinoma is a type of malignant tumor with a very high degree of malignancy and the incidence has continued to increase in recent years. Because of the aggressiveness and rapid expansion of pancreatic adenocarcinoma, patients with pancreatic cancer have an extremely low survival rate within five years on average, making it the worst prognosis of solid malignancies. Invasion and metastasis are the most basic features of cancer cells that are distinguished from normal cells. How to inhibit the pancreatic cancer cells from the primary tumor lesions, migration and invasion is one of the important issues that researchers need to solve. Thus, the project will elaborate the reason for the low expression of Ei24 in pancreatic cancer tissues of patients, and further reveals the molecular mechanism by which Ei24 regulates migration and invasion of pancreatic cancer cells. This project will provide the theoretical basis and direction of research for the development of targeted drugs and the treatment of pancreatic adenocarcinoma.
期刊论文列表
专著列表
科研奖励列表
会议论文列表
专利列表
DOI:10.1016/j.bbrc.2022.08.084
发表时间:2022-09
期刊:Biochemical and biophysical research communications
影响因子:3.1
作者:Xintong Pei;Huiyu Wang;P. Xu;Kuo Liang;Lin Yuan
通讯作者:Xintong Pei;Huiyu Wang;P. Xu;Kuo Liang;Lin Yuan
pHmScarlet is a pH-sensitive red fluorescent protein to monitor exocytosis docking and fusion steps.
pHmScarlet 是一种 pH 敏感的红色荧光蛋白,用于监测胞吐作用对接和融合步骤
DOI:10.1038/s41467-021-21666-7
发表时间:2021-03-03
期刊:Nature communications
影响因子:16.6
作者:Liu A;Huang X;He W;Xue F;Yang Y;Liu J;Chen L;Yuan L;Xu P
通讯作者:Xu P
Ei24与糖尿病的关系及作用机制的研究
- 批准号:31401174
- 项目类别:青年科学基金项目
- 资助金额:24.0万元
- 批准年份:2014
- 负责人:袁琳
- 依托单位:
国内基金
海外基金
