基于fMRI脑功能连接密度研究延年九转法干预CFS的脑-肠互动作用机制

CFS发病率高，持续时间长，截至目前，尚无特异性的治疗方法，成为严重困扰现代人的临床难题。研究表明，脑肠轴是CFS发生及防治的关键环节。中医传统功法具有形神兼治的功效，在CFS防治中具有优势。我们前期研究证实，延年九转法能改善CFS身心疲劳和胃肠功能，与脑区的功能活动密切相关。但其是否存在客观目标脑区？目标脑区与脑功能连接密度的关联有待验证。为此,我们提出假说：CFS复杂症状存在客观目标脑区，其功能活动与多脑连接密度是缓解CFS的关键中枢因素。为了验证这一假说，本项目以脑-肠互动为切入点，运用免疫学检测胃肠功能BGP物质，采用FCD客观反映激活的脑区与全脑的连接紧密度。从中枢神经脑网络水平观察脑功能连接枢纽区域的分布，明确功法起效的目标脑区，阐释延年九转法干预CFS的脑-肠互动作用机制，为传统功法“外治内应”效应及CFS的防治提供新的理论依据。

CFS has a high incidence and a long duration. Up to now, there is no specific treatment method, which has become a serious clinical problem that plagues modern people. Studies have shown that the brain-gut axis is a key link in the occurrence and prevention of CFS. Traditional Chinese medicine has the effect of treating both body and mind, and has advantages in the prevention and treatment of CFS. Our previous studies have confirmed that the Yan Nian Jiu Zhuan method can improve the physical and mental fatigue and gastrointestinal function of CFS, which is closely related to the functional activities of the brain. But does it have a target brain area? The correlation between the target brain area and the density of brain function connections remains to be verified. For this reason, we put forward the hypothesis that the complex symptoms of CFS exist in the target brain area, and its functional activity and multi-brain connection density are the key central factors to alleviate CFS. In order to verify this hypothesis, this project uses brain-gut interaction as an entry point, uses immunology to detect gastrointestinal function BGP substances, and uses FCD to objectively reflect the tightness of the activated brain area and the whole brain. Observe the distribution of brain function connection hub regions at the level of the central nervous brain network, clarify the target brain area where the exercises take effect, and explain the brain-gut interaction mechanism of the Yan Nian Jiu Zhuan method intervening in CFS, which is the traditional exercise method "external treatment and internal response" The effect and the prevention and treatment of CFS provide a new theoretical basis.