斑联蛋白（Zyxin）调控雄激素性秃发中毛囊微小化的机制研究

雄激素性秃发（Androgenic alopecia，AGA）是一种常见的慢性进行性脱发疾病，近年来受到越来越多的关注。虽然目前临床上已有较为成熟的治疗对策，但雄激素性秃发的治疗仍然存在可选药物少、治疗周期长等治疗瓶颈。在前期研究中，我们首次发现了斑联蛋白（Zyxin）在雄激素性秃发毛囊中高表达，且其对于毛囊生长有一定影响。基于前期研究结果，本课题拟通过体内及体外实验研究Zyxin调控AGA毛囊微小化的机制，包括：通过Zyxin注射或敲除小鼠及过表达或干扰Zyxin的毛囊及毛乳头细胞验证在毛囊微小化中的关键通路；同时通过体外细胞实验，明确Zyxin通过何种方式影响关键通路，进一步阐述其调控毛囊微小化的作用机制，为AGA的发病机制、临床治疗方案及新药物研发靶点提供理论依据。

Androgenic alopecia(AGA) is a common chronic progressive alopecia disease, which has attracted more and more attention in recent years. Although there are some mature treatment strategies in clinic, there are still some bottlenecks in the treatment of androgenic alopecia, such as less optional drugs, long treatment cycle and so on. In the previous study, we found for the first time that Zyxin is highly expressed in androgenic alopecia hair follicles, and it has a certain effect on the growth of hair follicles. Based on the results of previous studies, this study intends to study the mechanism of Zyxin regulating the miniaturization of AGA hair follicles in vivo and in vitro, including Zyxin injection or knockout of mice and hair follicles and dermal papilla cells that overexpress or interfere with Zyxin to verify the key pathways in hair follicle miniaturization. At the same time, through in vitro cell experiments, to clarify how Zyxin affects the key pathways, and further explain the mechanism of its regulation of hair follicle miniaturization, so as to provide a theoretical basis for the pathogenesis, clinical treatment and new drug development targets of AGA.