新型Aza-BODIPY类近红外共轭荧光染料的合成与光物理性质研究

Aza-BODIPY 荧光染料是近十年才发展起来的并受到广泛重视的一种较新的荧光化合物。本项目在国内外研究现状的基础上，通过合理的设计，合成新型具有长波长荧光发射和高荧光量子产率的Aza-BODIPY类近红外染料，拟从以下三个方面展开工作：（一）对Aza-BODIPY的母体结构进行拓展，即固定Aza-BODIPY母体结构中3、5位的苯环，使其分子的结构趋于平面化，从而更加有利于电子的离域，使谱带红移，提高荧光量子产率；（二）对上述染料外围引入活性官能团，对其进行外围的功能化修饰，得到具有特定功能的分子；（三）对Aza-BODIPY染料母体的外部进行合理修饰，将大的π共轭单元引入到染料母体的1、3、5、7位，增加分子的共轭程度，使谱带红移，提高荧光量子产率。

Aza-BODIPY-based fluorescent dyes are developed in the past ten years, they are relatively new fluorescent compounds which attracted much attention. On the basis of the research status at home and abroad, through reasonable design, to synthesize novel Aza-BODIPY near-infrared dyes with long-wavelength fluorescence emission and high fluorescence quantum yield. We will plan to carry out the work from the following three aspects: (one) to develop the parent structure of Aza-BODIPY, namely to fix the benzene rings in 3, 5 positions of Aza-BODIPY, then the molecular structure tends to be flat, it is thus more conducive to the delocalization of the electron, so the absorption and emission bands will red-shift and the fluorescence quantum yield will increase; (two) to introduce active functional groups on the periphery of the above dye, then we will modify the periphery of the compound , and thus get the molecules with specific functions; (three) to modify the periphery of the Aza-BODIPY parent dyes, we will introduce the large conjugated units into the 1, 3, 5, 7 positions of Aza-BODIPY, it will increase the degree of molecular conjugation, and thus the spectral bands will red-shift and the fluorescence quantum yield will be improved.