光刺激-响应增强同分异构体单分子尺度识别研究

有机化学中普遍存在同分异构现象。识别同分异构体对基础研究和实际应用具有非常重要的意义。针对同分异构体分子的识别，一方面大部分检测技术需要大量的样品分子；另一方面，结构极为相似的异构体分子，常规方法难以精准检测识别。针对上述关键科学问题，通过简单的电导测量技术，联合刺激-响应新策略是解决结构相似的异构体分子识别的关键，结合国际研究进展和申请人的研究基础，本项目拟开展以下研究工作：首先，通过简单的单分子电导测量方法解决异构体分子吡咯并吡咯二酮（DPP）和萘并二噻吩（NDT）单分子尺度识别问题，建立结合光刺激-响应的策略增强异构体识别的普适性新方法；其次，结合理论模拟，对光辐射下异构体分子电导变化的理论机制进行深入探究，为光电响应器件的设计提供关键基础；最后，在实现建立光辅助增强异构体分子识别普适性新方法与深入理解异构体分子光电响应机制基础上，为有机光电材料分子的设计提供理论指导。

Isomerism is a common phenomenon in organic chemistry. Identification of isomers is very important for basic research and practical application. For isomer recognition, on the one hand, most detection techniques require a large number of sample molecules; In addition, it is difficult to detect and identify isomers with similar structures by conventional methods. Aiming at these critical issues, through simple conductivity measurement technology, joint stimulus and response to the new strategy will be the key to solve structural isomer of similar molecular recognition, combined with the international research progress and the applicant's research foundation, this project will focus on the following issues: (1) through a simple single conductance measurement method to solve isomer molecules pyrrole and pyrrole diketone (DPP) and the naphthalene and thiophene (NDT) single molecule scale identification problem, with light stimulus-response strategy should be established to strengthen the universality of the isomer recognition new method; (2) combined with theoretical simulation, the theoretical mechanism of the changes of molecular conductance of isomers under light radiation will be deeply explored, which provides a key foundation for the application design of photoelectric response devices. (3) based on the establishment of a new universal method of photoassisted enhanced isomer recognition and a deep understanding of the photoelectric response mechanism of isomer molecules, the breakthroughs in this field will provide theoretical guidance for the design of organic photoelectric materials.