幽门螺杆菌(H. pylori)感染与胃癌发生发展密切相关，血管新生在其中发挥了重要作用，如何抑制血管新生成为国内外研究的热点。我们前期研究发现，以中医健脾解毒法组方的中药复方可降低H. pylori长期感染诱发C57BL/6小鼠胃癌发生率，减少小鼠胃粘膜微血管密度（MVD）、抑制血管内皮生长因子（VEGF）表达是其重要机制，但确切机理尚不清楚。PTEN/PI3K/AKT信号通路是调控血管新生的重要途径。本研究在前期研究基础上，探讨健脾解毒复方调控PTEN/PI3K/AKT信号通路抑制VEGF表达和血管新生，降低H. pylori感染诱发C57BL/6小鼠胃癌的机制，明确该方防治胃癌的作用靶点。丰富中医关于H. pylori感染的治疗方法，阐明中医健脾解毒治法的现代科学内涵，为其临床应用提供实验和理论依据。

Helicobacter pylori（H. pylori）infection correlates to the genesis and development of the gastric cancer, and angiogenesis plays an important role in this project. How to inhibit angiogenesis becomes a research hotspot at home and abroad.In a previous study, we found that Chinese herbal compound, which was based on traditional Chinese medicine（TCM） method of invigorating spleen and detoxification, could reduce the incidence of C57BL/6 mouse gastric cancer induced with H.pylori long-term infection. The important mechanisms is to decrease microvessel density(MVD) in gastric mucosa of C57BL/6 mice and inhibit vascular endothelial growth factor(VEGF) expression, but the mechanisms is not clear precisely. PTEN/PI3K/AKT signaling pathway is an important way of regulation of angiogenesis. At the base of former research, in this study we investigate the mechanisms of Jianpi Jiedu Recipe on inhibiting VEGF expression and angiogenesis and reducing the incidence of C57BL/6 mouse gastric cancer induced with H.pylori infection via PTEN/PI3K/AKT signaling pathway，therefore make clear the Jianpi Jiedu Recipe action target of prevention and treatment of gastric cancer. To perfect the treatment method of TCM on H. pylori infection，to clarify the mdern and scientific connotation of TCM method of invigorating spleen and detoxification, and to provide the experimental and theoretical basis for its clinical application.