官能团化烯丙基衍生物能在过渡金属催化下原位生成π-烯丙基金属复合物，并通过释放二氧化碳或开环等途径形成两亲性偶极子，参与多类不对称环化反应。目前此类偶极子前体的种类和骨架均相对有限，且多数仅生成1,3-或1,4-偶极子参与反应，限制了相关不对称环化反应的发展。本项目拟设计多类新颖的含酸性氢等官能团化烯丙基衍生物，在手性金属配合物作用下原位形成π-烯丙基金属复合物，并作为拉电子基团协助分子中酸性氢离去，生成1,4-、1,5-甚至1,6-等偶极子，进而发展多种具有挑战性的不对称环化反应。我们还将重点设计并发展系列含有氢键供体的手性双功能膦配体，拟通过协同活化作用催化环化反应，高效、高立体选择性地构建含多手性中心的多环骨架化合物。

The asymmetric annulation reactions of dipoles containing π-allylmetal complexes, which are in situ generated from diversely functionalized allylic derivatives under transition metal catalysis, represent powerful tools for the rapid construction of chiral cyclic skeletons. However, the reported dipole precursors are still relatively limited, and most of them only produce 1,3- or 1,4-type dipoles. Here, we aim to design an array of functionalized allylic derivatives with acidic groups, which would form π-allylmetal complexes under metal catalysis. The electron-withdrawing effect of such metal complexes would facilitate further deprotonation to generate 1,4-, 1,5-, or even 1,6-dipoles, and undergo a diversity of challenging asymmetric annulations. In addition, some new bifunctional phosphine ligands with H-bonding donors will be designed. They may play an important role in the related asymmetric annulations to construct diverse polycyclic frameworks with multiple stereogenic centers via a concerted activation strategy.