前列腺癌的发病机制被认为与许多基因相关。最近研究报道TMPRSS2-ETS相关融合基因对诊断早期前列腺癌及淋巴结转移预警具有较高的特异性，基因检测是判断肿瘤生物学性状的一种重要方法，但是基因检测均需要取得病理标本后进行。如何能无创性筛查预测融合基因，为前列腺癌早期预警提供支持。课题组拟将多模态磁共振成像筛查前列腺癌的影像特征与融合基因检测分析相关联，探索出利用影像特征对前列腺癌相关融合基因表型特征的预测，并探索阐述其病理机制，揭示前列腺癌发生、发展、淋巴结转移机制，对预判前列腺癌进展、转移具有前瞻性预警作用，为早期干预治疗提供靶点。

The pathogenesis of prostate cancer is thought to be related to with many genes. Many studies have reported that TMPRSS2-ETS fusion genes have high specificity in early warning of early prostate cancer and lymph node metastasis. It is an important way for genetic testing to determine the biological characteristics of the tumor, but genetic testing is required to obtain pathological specimens. How can we noninvasively detect the fusion genes and provide early warning of prostate cancer? The purpose of our study is to explore the relationship between the multimodal magnetic resonance imaging features of prostate cancer and fusion genes, and to explore its pathological mechanism. We may try to predict the progress，metastasis and recurrence of prostate cancer, and to provide a target treatment in early intervention.