人体系统低体温热响应机制及调控方法研究

亚低体温是急救医学中重要的治疗手段，但重度低体温却具有极高的致命性。人体所耐受低体温及其形成过程中对机体保护和损伤机制一直是临床医学界关注的热点，而其中所涉及的热生理调节和人体系统热量传输等生物传热传质关键问题一直未得到有效解决。从工程热物理学视角研究人体系统传热机理，是阐明人类恒温特性、人体系统热量传输、动态热平衡形成-失稳-重塑的关键所在。本项目基于体表血供分区解剖结构，绘制体表血液灌注率分布图谱，揭示血液灌注-皮肤热响应耦合机制；提出血管网络血液流动-血液灌注-机体热状态耦合的体温调控模型，构建动静脉血管网络-组织器官传热耦合模型并发展高效的计算方法，解读人体系统低体温形成及复温过程中机体热响应及热量传输机理；基于液态金属柔性电子技术，发展柔性可穿戴式体表选择性加热技术，探索建立低体温症复温优化策略。本研究可望在人体系统热生理基础理论与应用研究方面取得新的突破。

Sub-hypothermia is an important treatment in emergency medicine, but severe hypothermia is very lethal. The mechanism of body protection and injury in the process of hypothermia tolerance and its formation has always been a hot topic in clinical medicine, and the key problems of biological heat and mass transfer, such as thermo-physiological regulation and heat transfer in human body system, have not been effectively solved. To study the heat transfer mechanism of human body system is the key to clarify the constant temperature characteristics of human body system, heat transfer of human body system and the formation, instability and remodeling of dynamic heat balance. In this project, based on the anatomical structure of blood supply division on the body surface, the distribution map of blood perfusion rate on the body surface is drawn to reveal the coupling mechanism of blood perfusion skin thermal response; the temperature control model of blood flow blood perfusion body thermal state coupling of vascular network is proposed, the coupling heat transfer model of the vascular network-tissue is constructed, and efficient calculation method is developed, which is used for interpretation of the thermal response and heat transfer mechanism of the body during the formation and rewarming of hypothermia. Based on the liquid metal flexible electronics, a flexible wearable selective heating technology was established to explore the optimal strategy of hypothermia rewarming. This study is expected to make a new breakthrough in the basic theory and application of human system thermo-physiology.