糖皮质激素受体介导中枢可塑性调控运动干预前列腺炎慢性疼痛的机制研究

盆底疼痛持续和反复发作是慢性前列腺炎/慢性盆腔疼痛综合征的主要症状，然而疼痛慢性化机制缺乏深入研究。我们前期工作发现盆底疼痛持续反复的前列腺炎患者存在中枢系统功能和结构的重塑，且中枢可塑性机制可能参与前列腺炎疼痛慢性化。本项目将研究(1)前列腺炎慢性疼痛调控中枢可塑性和中枢糖皮质激素受体(GR)的机制；(2)GR信号通路介导中枢可塑性调控前列腺炎疼痛慢性化的机制；(3)运动治疗对中枢可塑性和中枢GR的再平衡以及GR介导中枢可塑性对运动干预前列腺炎慢性疼痛的调控机制。这些研究对分析前列腺炎慢性疼痛调控中枢可塑性机制，揭示GR介导中枢可塑性调控前列腺炎疼痛慢性化机制以及前列腺炎运动治疗中枢调控机制具有重要的意义。

Persistent and repeated pelvic pain is the main symptom of chronic prostatitis / chronic pelvic pain syndrome, while the mechanism of chronic pelvic pain is lack of deep research. Our previous work has found that the function and structure of the central system would be remolded in patients with persistent and repeated pelvic pain, and the central plasticity mechanism might be involved in the chronicity of pelvic pain in patients. This project will study (1) the mechanism of chronic pelvic pain regulating central plasticity and central glucocorticoid receptor (GR); (2) the mechanism of GR signaling pathway mediated central plasticity regulating chronicity of pelvic pain; (3) the rebalancing of central plasticity and GR by exercise therapy and the mechanism of GR mediated central plasticity in exercise therapy for chronic pelvic pain. These studies are of great significance to analyze the mechanism of chronic pelvic pain regulating central plasticity and to reveal the mechanism of GR mediated central plasticity regulating chronicity of pelvic pain and the mechanism of central regulation in exercise therapy for chronic pelvic pain in prostatitis patients.