基于“时-空”环境刺激响应修饰定量生物药剂学分类系统的中药复方（麻杏石甘汤）配伍机制研究新方法

“配伍”是中医药传统理论的核心内容之一，方剂是中医药辨证施治的重要载体。建立合理的方法阐述方剂配伍所产生的药物间相互作用的科学内涵是中医药理论研究的关键问题。本研究提出“中药复方配伍后具有环境响应能力的组分以‘类制剂’的形式影响其它药物组分生物药剂学属性而影响复方发挥药效”的科学假说，以经典名方麻杏石甘汤为研究模型，以其中具有“调和诸药”功能的甘草为切入点，研究甘草各组分热力学稳态“响应体系”的空间形成机制及其对其它组分生物药剂学属性动力学的影响，进而分别从时-空两个维度修饰生物药剂学分类方法，利用修饰后的定量生物药剂学分类方法更准确地表征复方内部各组分/组分群的体内变化过程。拟建立一种基于“时-空”环境刺激响应的修饰定量生物药剂学分类系统用以研究中药复方配伍机制。力求对中药配伍理论研究从时空动态过程做出突破性阐述，推进中药传统理论发展为完整的知识体系。

"Compatibility" is one of the core contents of traditional Chinese medicine theory, prescription is an important carrier of syndrome differentiation and treatment of traditional Chinese medicine. To establish a reasonable method to explain the scientific connotation of drug-drug interaction caused by the compatibility of prescriptions is the key problem in the theoretical research of traditional Chinese medicine. In this study, a scientific hypothesis was put forward that "the components with environmental response ability after compatibility of traditional Chinese medicine compound affect the oral biopharmaceutical properties of other pharmaceutical components in the form of" preparations like "and affect the efficacy of the compound". Taking the classic famous prescription Maxingshigan decoction as the research model, and the glycyrrhiza with the function of "harmonizing various drugs" as the breakthrough point, the thermodynamic steady state of each component of Glycyrrhiza was studied“ The spatial formation mechanism of response system and its influence on the dynamics process of biopharmaceutical properties of other components, and then modify the biopharmaceutical classification method from two dimensions of time and space respectively, and use the modified quantitative biopharmaceutical classification method to more accurately characterize the in vivo change process of components / groups within the compound. A modified quantitative biopharmaceutical classification system based on "Time-space" environmental response is proposed to study the compatibility mechanism of traditional Chinese medicine. Strive to make a breakthrough in the research of traditional Chinese medicine compatibility theory from the dynamic process of time and space, and promote the development of traditional Chinese medicine theory into a complete knowledge system.