基于腹-背侧脑网络交互探讨头皮针对脑卒中后命名障碍的语言功能重塑机制研究

命名功能障碍，是脑卒中后失语症最常见的语言障碍，其所致沟通技能损伤严重影响了患者的生活质量和社会参与。调控词汇-语义过程的腹侧脑网络和调控音韵编码过程的背侧脑网络交互作用是命名障碍恢复的关键神经网络机制之一，命名功能的恢复过程被认为是腹-背侧脑网络之间协同交互并进行重组的结果。且针刺可以调控语言相关脑网络。前期研究表明头皮针对卒中后失语的命名功能可产生积极影响。据此推测头皮针可通过调控腹-背侧脑网络中语音/语义子网络的重组及其网络内外脑区间的协同变化以改善命名功能障碍。本研究以慢性失语命名障碍患者为研究对象，对患者行头皮针治疗，通过近红外技术，基于病灶-症状映射分析，探索命名障碍的特异语言损伤与腹-背侧脑网络的脑区分布相关性；并采用结构/功能核磁共振多模态评估观察，分析头皮针对卒中后慢性失语症患者腹-背侧脑网络连接与子网络属性的影响，从而阐明头皮针影响命名障碍的语言功能重塑机制。

Naming deficit is one of the most common and debilitating impairments in individuals with chronic aphasia after stroke. Communication skills damage caused by which can severely affect the quality of life and social participation of patients. The mechanism of naming deficit recovery can be considered as the interaction between lexical-semantic (ventral networks) and phonological encoding (dorsal networks). Evidence showed that acupuncture could regulate the language-related network. Our previous studies have shown that scalp acupuncture had a positive impact on the naming function of patients with aphasia after stroke. Therefore, we can speculate that scalp acupuncture can improve the naming deficit by regulating reorganization of speech sound / semantic subnetworks and synergetic changes of brain regions within and outside of the ventral-dorsal networks. In this research, patients with naming deficit after stroke will be treated by scalp acupuncture. In order to clarify the mechanism of scalp acupuncture on language function remodeling in those patients, functional near-infrared spectroscopy (fNIRS) will be used to explore the relationship between the specific language impairment of naming deficit and the distribution of ventral-dorsal brain network based on the lesion-symptom mapping analysis; Structural/functional magnetic resonance will be used to analyze the influence of scalp acupuncture on the connection of ventral- dorsal brain network and the properties of subnetwork in patients with chronic aphasia after stroke.