冲击载荷下肺脏组织的力学行为和损伤机制研究

肺脏作为一种重要器官，其在冲击载荷下的损伤将严重影响生物体的生命特征。针对肺脏冲击损伤机制的研究大多拘泥于医学病理分析和整体肺器官冲击损伤，缺乏对不同组分肺组织的力学响应规律和多尺度损伤机理的深入认识，极大地制约了肺冲击损伤的早期诊断、治疗和预防。本项目以冲击载荷下肺脏组织的损伤为切入点，基于力学性能试验、数值仿真和病理分析研究，针对肺脏组织的冲击损伤机理开展研究。拟发展宽应变率下肺脏组织力学响应的测试方法，准确测量肺脏组织的率相关力学性能，建立合理的本构模型以及高效的肺脏组织细观和宏观有限元模型；结合肺脏冲击损伤试验和病理分析，阐明应变率对其力学响应的影响规律，揭示冲击载荷下肺脏组织的应变率效应和损伤机制，明确损伤与其生命体征的关系。本项目对全面理解肺脏组织冲击损伤的产生和演化机理，开创肺脏器官冲击损伤的诊断、评估和治疗体系，及时挽救战场士兵及受伤民众的生命具有重要的意义。

As an important organ, the damage of lung under impact load will seriously affect the life characteristics of organism. The research on the mechanism of lung impact injury is mostly limited by the medical pathological analysis and the whole lung organ impact injury. The lack of in-depth understanding of the mechanical response law and multi-scale damage mechanism of different components of lung tissue greatly restricts the early diagnosis, treatment and prevention of lung impact injury. In this project, based on the mechanical property test, numerical simulation and pathological analysis, the impact damage mechanism of lung tissue was studied. It is proposed to develop a method to measure the mechanical response of lung tissue under wide strain rate, accurately measure the rate related mechanical properties of lung tissue, establish a reasonable constitutive model and an efficient meso and macro finite element model of lung tissue; combined with the lung impact injury test and pathological analysis, the effect of strain rate on its mechanical response is clarified, and the strain rate of lung tissue under impact load is revealed The relationship between injury and vital signs was clarified. This project is of great significance to fully understand the generation and evolution mechanism of lung tissue impact injury, create the diagnosis, evaluation and treatment system of lung organ impact injury, and save the lives of soldiers and injured people in the battlefield in time.