催眠诱导深度静息状态下双相情感I型和II型障碍神经机制的脑电研究

双相情感障碍主要亚型I型（BD I）和II型（BD II）稳定有效的生物鉴别标记物缺乏。研究表明其核心病理特征与中央执行、默认模式网络的结构与功能失衡及对其他系统的异常调控有关。但在亚型中未发现基于此的充分鉴别证据。这可能由于清醒时患者认知功能和脑网络表征易受所处情绪相影响。因此我们拟通过无特定暗示项目的中性催眠诱导更深层的静息状态并记录EEG活动，分析EEG时频特征、功率包络连通性（PEC）和微状态，进行催眠下BD I、BD II、重症抑郁（MDD）和健康志愿者间，清醒/催眠下兴奋期和抑郁期BD亚型间的特征比较，进一步探讨BD I和BD II的脑网络受损机制。我们假设中性催眠下BD I和BD II存在与健康个体和MDD不同的时频、PEC特征和微状态，不同情绪相的亚型患者存在更稳定的异常功能指标。本项目有助于理解不同意识状态下双相的神经病理生理机制，为建立更稳定的生物亚型诊断标准奠定基础。

Stable and effective biomarkers for the identification of major subtypes of bipolar disorder——I (BD I) and II (BD II) have long been scarce. Studies shown the core pathological features of bipolar disorder are related to their structural and functional imbalance between the Central Executive Network and Default Mode Network, and their abnormal regulation of other systems. However, related evidence for bipolar subtype differentiation is inadequate. This may be due to that the cognitive function and brain network manifestation of awake subtypes are easily affected by their affective states. Therefore we aim to analyze and make comparison of the EEG time-frequency and power envelope connectivity (PEC) characteristics as well as microstate during neutral hypnosis-induced deeper resting state among BD I, BD II, major depression (MDD), and healthy volunteers, as well as among bipolar subtypes in manic/hypomanic and depressive states during awake and hypnosis, to further explore the brain network impairment in BD I and BD II. We hypothesize that BD I and BD II had different above-mentioned characteristics, and bipolar subtypes of different affective states had more stable characteristics under neutral hypnosis. This study is assistant to understand the neuropathophysiological mechanisms of bipolar disorder in altered state of consciousness and lays a foundation for the establishment of more stable biological diagnostic criteria for bipolar subtypes.