泡沫相高效、可连续化制备结构可调聚合物微球的理论基础研究

结构可调聚合物微球作为一种功能材料，具有广阔的应用前景。通过研究找到一种简单、高效、可调控结构、可连续化生产的聚合物微球的制备方法，对聚合物微球的发展具有重要的意义。项目申请人在国际上首次提出了一种在泡沫相中制备聚合物微球的新方法，该方法的特征符合所期望的简单、高效、结构可调、可连续化生产聚合物微球的要求。本项目拟开展泡沫相制备聚合物微球的系统研究，以揭示该方法的科学本质，阐明该方法能够实现高效性、结构可调性和连续化生产的理论基础。具体包括：（1）结合泡沫相即气、液、固三相共存下的相分离行为研究该方法的科学本质和高效性的理论基础；（2）基于聚合物结构、分子量、溶剂溶解度参数和极性等要素研究微球结构调控的普遍规律；（3）研究该方法的连续化过程，基于物料和热量平衡获得用于指导连续化生产的理论基础。本项目是聚合物微球制备领域的重要发现，研究结果可以为高效和连续生产结构可调聚合物微球奠定理论基础。

Polymeric microspheres with different internal structures have been widely used due to their attractive characteristics. It is significant to develop an effective approach for high throughout production of polymeric microspheres with different internal structures in a continuous process. In our previous work, a new method to produce polymeric microspheres with different internal structures in a foam phase has been developed and it has been seen time-saving, high yield and continuous process. The characteristics of the new method to prepare polymeric microspheres in a foam phase is desirable. Therefore, in this work we are trying to study the method to produce polymeric microspheres in a foam phase systematically. The main contents are as follows: (1) Study the phase separation behaviors in the foam phase in which gas, liquid and solid phases present simultaneously, in order to understand the scientific nature of the new method and obtain the theoretical evidences for its efficiency. (2) Investigate the internal structures of polymeric microspheres as a function of polymer structures, their molecule weights, the solubility parameters of solvents (including porogen) and their polarities to establish the general rules to control the structure of polymeric microspheres. (3) Develop the preparation process of producing polymeric microspheres in a foam phase as a continuous process and build a mathematic model based on mass balance and thermal balance to calculate the optimal operation parameters, which is aimed to obtain theoretical understandings on the continuous production of polymeric microspheres. The new method of producing polymeric microspheres in a foam phase is a huge breakthrough in the area and it enables a time-saving method with high yield for producing polymeric microspheres with different internal structures in a continuous process.