慢性痛患者注意抑制损伤的认知神经机制及干预研究

慢性痛患病率高，给患者带来痛苦，给家庭、社会造成巨大经济压力。随着我国老龄化进程，慢性痛问题将不断加剧。慢性痛的医疗干预疗效不显著，认知-行为因素却起着重要影响。疼痛相关的注意偏向对于疼痛恐惧、疼痛评级、高水平身体机能受损和情绪忧虑等都会造成影响，可能是慢性痛的重要成因。注意抑制功能损伤是疼痛相关注意偏向产生的关键原因。但是，以往大量研究仅采用直接呈现疼痛线索的方式，考察自下而上的注意加工，鲜有研究从注意控制角度，考察自上而下的注意控制功能及其神经基础。本项目拟以注意的抑制功能为切入点，探明慢性痛患者的注意抑制对疼痛相关信息的功能作用，以及该功能作用的神经基础。进而，通过前瞻性研究，考察注意抑制能力与慢性痛发展的渐变关系。最后，结合高精度经颅直流电刺激这一安全有效的神经调控技术，提升慢性痛患者对疼痛相关信息的注意抑制能力，帮助疼痛患者更科学和有效的管理疼痛，从而促进慢性痛的临床治疗效果。

The high incidence of chronic pain brings pain to patients, and creates great economic pressure to families and society. With the aging process of our country, the chronic pain will be increasing. The effect of medical intervention on chronic pain is not significant, but cognitive behavior factors play an important role. The attention bias of pain can affect pain fear, pain rating, high level physical function damage and emotional anxiety, which may be an important cause of chronic pain. Attention inhibition function damage is the key reason for pain related attention bias. However, in the past, a large number of studies only used the way of presenting pain clues directly, and looked at the bottom-up attention processing. Few studies have studied the top-down attention control function and its neural basis from the point of view of attention control. This project aims to explore the function of attention inhibition on pain related information and the neural basis of the function of chronic pain patients. Then, through prospective research, the gradual relationship between attention inhibition and chronic pain development was investigated. Finally, combined with the high-precision transcranial direct current stimulation, this safe and effective neuroregulation technology can improve the attention and inhibition ability of pain related information of chronic pain patients, help pain patients to manage pain more scientifically and effectively, and promote the clinical treatment effect of chronic pain.