基于防治糖尿病的多基原车前子药效物质基础及品质评价研究

“多基原”中药的品质和生物效应等同性问题是中药现代化进程中普遍关注的难题，而仅仅阐述化学成分的差异性难以全面的揭示品种之间的差异化的科学内涵。中国药典中车前子来源于两个基原，课题组研究发现这两个品种在化学成分上和治疗糖尿病时均有显著性的差异，但对其引发的科学内涵尚不明确。基于此，本研究在中医理论指导下，以车前子的两个基原品种的为研究对象，以防治糖尿病为方向，采用中药化学、分析化学、中药药理学和药物代谢组学相结合的研究方法和技术，采用化学/药效关联分析，鉴定药效成分（群）的差异性问题，阐述多基原车前子的药效物质基础及其在体内的整体功效。本研究为多基原药材的质量和生物效应等同性共性问题的探索研究提供了借鉴，同时也为车前子及其复方在防治糖尿病的新药开发提供理论依据。

The quality and biological effect of "multi-species" traditional Chinese medicine is a common problem in the process of modernization of traditional Chinese medicine. It is difficult to fully reveal the scientific connotation of the differentiation between varieties only by expounding the differences of chemical components. Plantaginis Semen in Chinese Pharmacopoeia comes from two species. The research team found that there were significant differences in chemical composition and treatment of diabetes between the two species, but the scientific connotation of its research and development is not clear. Based on this, under the guidance of the theory of traditional Chinese medicine, this study takes the two original species of Plantaginis Semen as the research object, and takes the prevention and treatment of metabolic syndrome as the direction, methods and techniques of traditional Chinese medicine chemistry, analytical chemistry, pharmacology of traditional Chinese medicine and metabonomics were used to identify the differences of effective components (groups) by using chemical /pharmacodynamic correlation analysis, and to elaborate the material basis of pharmacodynamic effect and its overall effect in the body of multi base of Plantaginis Semen. This study provides a reference for the exploration and research on the quality and biological effects of multi-source traditional Chinese medicine, it also provides a theoretical basis for the development of new medicines for the prevention and treatment of diabetes by Plantaginis Semen and its compound.