“整合论治”策略下菊苓颗粒抗痛风病基础研究

痛风病是高血尿酸及尿酸盐沉积密切相关的进展性、致残性代谢疾病。菊苓颗粒是国医大师颜正华痹证治验，兼具缓解关节肿痛、降低高血尿酸明确疗效，突破痛风病临床割裂、单一用药的局限，体现中医药“整合论治”优势与特色。在前期临床及制剂基础上，研究菊苓颗粒整合论治痛风病的物质基础与药效机制，是临床治疗的需求。.前期已发现炎症存在于痛风病不同阶段，全程炎症可能是高血尿酸与尿酸盐沉积的关联纽带。据此提出假说：菊苓颗粒及其活性成分通过调控尿酸代谢靶点群、干预炎症启动及级联扩大，以实现截断高血尿酸、逆转尿酸盐沉积，整合论治痛风病的临床疗效。本研究以多学科手段，逐层明晰菊苓颗粒药效物质基础，并应用优势动物模型及体外阻断技术，多角度探究菊苓颗粒药效机制。为临床提供成分、机制清晰的抗痛风病中药及科学用药方案，为阐释中药整合效应提供新靶点，以拓展中医临床优势、示范北京地区名医经验传承与转化。临床意义突出、学术创新明确。

Gout disease is a high prevalence and progressive disabling metabolism disease, which closely related to hyperuricemia and topical urate crystal deposition. Juling granules as an experience formula for Bi Zheng therapy is developed by National TCM Great Master Yan Zhenghua. This formula has favorable effects in lowering uric acid levels and reliving gouty inflammation. This formula focuses on the holistic treatment for gout disease, which steps across the limitations of gout therapy separately. Our previous studies have proved its safety and efficacy of gout disease as well as improved its pharmaceutics technology. The present study is aimed to further explore the chemical substances and mechanism of Juling granules on treating gout disease with the holistic therapeutic strategy. It will meet the urgent demands for treatment of gout disease. Recent researches showed that inflammation always presented in each process of gout disease. Inflammation throughout the whole pathogenic progress of gout may be an important link between hyperuricemia and urate deposition. Therefore, we proposed a hypothesis that the holistic therapeutic strategy of Juling granules on gout disease is realized by regulating targets of urate metabolism and intervening inflammatory cascade reaction. In order to prove this hypothesis, a set of modern technologies will be used in this study to explore the anti-gout effects of Juling granules. This study will provide an effective anti-gout agent with clear the chemical components of this experience formula and clarified pharmacological mechanism, and formulate a reasonable medication scheme of Juling granules, which may be exampling the application and inheritance of medical experience of National TCM Great Master in Beijing. This study has a high significance to translate the clinical experience to new drug development.