Ru(II)-Pd(II)配位分子笼催化的芳香杂环的选择性烷基化研究

烷基取代芳香杂环化合物是很多药物分子和有机功能材料的基本结构，在芳香杂环上精准引入烷基基团，尤其是通过不对称催化的方式对映选择性引入具有十分重要的科学意义和应用前景。本项目以Ru(II)-Pd(II)配位分子笼为核心，探索仿酶催化体系，建立具有特定功能的 “分子手术室”，并将其用于芳香杂环化合物的选择性烷基化（区域选择性和对映选择性）。不同于以前C2对称催化体系，本项目利用手性空间群（D4）催化来解决合成化学中的难题。项目的顺利进展不仅能推动仿酶催化科学研究的发展，还能加速小分子杂环药物的开发与升级换代。

Alkyl heteroarenes are important units in many bioactive compounds and functional materials, development of efficient method to install alkyl group on the exact position of the heterocycles, especially the enantioselective transformation, would be very helpful for the synthetic chemists. In imitation of the enzymatic mechanism, a special micro “operating room” would be developed for the selective alkylation with alkyl radical intermediate. Different from previous C2-symmetric catalysis system, D4 chiral space group will be used to figure out the practical problem. The system described here will be a great achievement in the area of asymmetric catalysis and also will accelerate the development of heteroarenes contained drugs.